| Title: | Accelerometer-measured weekend catch-up sleep and incident dementia: A prospective cohort study |
| Journal: | Alzheimer's & Dementia |
| Published: | 19 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41416569/ |
| DOI: | https://doi.org/10.1002/alz.71001 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.71001 |
Publication 17092
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Abstract
INTRODUCTION: Healthy sleep may support cognitive health, but the role of weekend catch-up sleep is unclear.</p>
METHODS: Among 83,776 dementia-free UK Biobank participants aged ≥50 years, sleep duration was estimated from 7-day accelerometer data (2013-2015). Weekend catch-up sleep was defined as the weekend-weekday sleep duration difference. Cox regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause dementia associated with weekend catch-up sleep.</p>
RESULTS: During follow-up (median: 8.0 years), 713 participants developed all-cause dementia. Compared with ≤0.5 h, HRs for all-cause dementia across catch-up sleep categories were 0.91 (0.74-1.11) for > 0.5-1 h, 0.64 (0.49-0.86) for > 1-1.5 h, 0.84 (0.60-1.16) for > 1.5-2 h, and 0.83 (0.60-1.16) for > 2 h. The association was stronger among participants with weekday sleep < 8 h (HR: 0.49, 0.29-0.81 for > 1-1.5 h) but non-significant in those with ≥8 h (p-interaction = 0.039).</p>
DISCUSSION: Moderate weekend catch-up sleep was linked to lower dementia risk, especially among individuals with less weekday sleep.</p>
HIGHLIGHTS: In this prospective cohort study, moderate accelerometer-measured weekend catch-up sleep was linked to a reduced risk of dementia, with 1-1.5 h associated with the lowest risk. The relation was more pronounced in participants with weekday sleep duration < 8 h/day, but non-significant among those with a longer weekday sleep. Similar associations were observed across the subgroups stratified by sociodemographic and lifestyle factors.</p>
14 Keywords
- Accelerometry
- Aged
- Cohort Studies
- Dementia
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Sleep
- Time Factors
- United Kingdom
12 Authors
- Hui Chen
- Ting Shen
- Mengjia Zhao
- Lusha Tong
- Guiyu Lu
- Wenchang Yang
- Fengchang Li
- Chengwu Feng
- Geng Zong
- Xiao Tan
- Tianyi Huang
- Changzheng Yuan
1 Application
| Application ID | Title |
|---|---|
| 55005 | Common risk factors and mechanisms in cardiometabolic diseases and neurodegenerative diseases |
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