| Title: | A human pan-disease blood atlas of the circulating proteome |
| Journal: | Science |
| Published: | 18 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41066540/ |
| DOI: | https://doi.org/10.1126/science.adx2678 |
| URL: | https://kclpure.kcl.ac.uk/portal/en/publications/af601a73-7a16-4617-ace9-0f409099a78d |
Publication 17104
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Abstract
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and body mass index, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8262 individuals and up to 5416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.</p>
14 Keywords
- Adult
- Age Factors
- Atlases as Topic
- Blood Proteins
- Body Mass Index
- Disease
- Female
- Humans
- Male
- Middle Aged
- Precision Medicine
- Proteome
- Proteomics
- Sex Factors
111 Authors
- María Bueno Álvez
- Sofia Bergström
- Josefin Kenrick
- Emil Johansson
- Mikael Åberg
- Murat Akyildiz
- Ozlem Altay
- Hilda Sköld
- Konstantinos Antonopoulos
- Emmanouil Apostolakis
- Yasin Hasan Balcioglu
- Anna Bergström
- Göran Bergström
- Sophia Björkander
- Suzanne Egyhazi Brage
- Petter Brodin
- Lynn Butler
- Sara Cajander
- Hanna Danielsson
- Murat Dayangac
- Gizem Dinler-Doganay
- Levent Doğanay
- Gunilla Enblad
- Malin Enblad
- Linn Fagerberg
- Sara Falck-Jones
- Anna Färnert
- Mattias Forsberg
- Laura Gonzalez
- Anders Gummesson
- Karin Gunnarsson
- Iva Gunnarsson
- Ulf Gyllensten
- Göran Hesselager
- Andreas Hober
- Martin Höglund
- Marie Holmqvist
- Begum Horuluoglu
- Rebecka Hultgren
- Maria Jesus Iglesias
- Helena Janols
- Fredric Johansson
- Anette Johnsson
- Lars Klareskog
- David Kotol
- Inger Kull
- Marika Kvarnström
- Maximilian Julius Lautenbach
- Ulrika Liljedahl
- Henrik Lindman
- Cecilia Lindskog
- Miklos Lipcsey
- Ingrid E Lundberg
- Adil Mardinoglu
- Erik Melén
- Lingqi Meng
- Anne-Sophie Merritt
- Jan Mulder
- Mai Thi-Huyen Nguyen
- Jessica Nordlund
- Anna Norrby-Teglund
- Antonella Notarnicola
- Piotr Nowak
- Jacob Odeberg
- Per Oksvold
- Tomas Olsson
- Leonid Padyukov
- Karlis Pauksens
- Fredrik Piehl
- Elisa Pin
- Fredrik Pontén
- Natallia Rameika
- Anton Reepalu
- Joy Roy
- Jochen M Schwenk
- Meltem Sen
- Antti Siika
- Oscar E Simonson
- Åsa Sivertsson
- Tobias Sjöblom
- Evelina Sjöstedt
- Lovisa Skoglund
- Anna Smed-Sörensen
- Klara Sondén
- Anders Sönnerborg
- Karin Stålberg
- Kristoffer Strålin
- Jonas Sundén-Cullberg
- Christopher Sundling
- Thanadol Sutantiwanichkul
- Fernanda Costa Svedman
- Mattias Svensson
- Elisabet Svenungsson
- Tadepally Lakshmikanth
- Khue Hua Tran-Minh
- Hasan Türkez
- Christian Unge
- Per Venge
- Marie Wahren-Herlenius
- Jakob Woessmann
- Hong Yang
- Umit Haluk Yeşilkaya
- Meng Yuan
- Mujdat Zeybel
- Cheng Zhang
- Wen Zhong
- Martin Zwahlen
- Kalle von Feilitzen
- Peter Nilsson
- Fredrik Edfors
- Mathias Uhlén
1 Application
| Application ID | Title |
|---|---|
| 174156 | Integrating and Validating Human Disease Blood Atlas with UK Biobank Plasma Profiles |
Enabling scientific discoveries that improve human health