| Title: | Night shift work and its interaction with sleep duration and chronotype, and risk of cardiovascular-kidney-metabolic diseases in the UK Biobank |
| Journal: | European Journal of Preventive Cardiology |
| Published: | 18 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41411331/ |
| DOI: | https://doi.org/10.1093/eurjpc/zwaf774 |
| URL: | https://academic.oup.com/eurjpc/advance-article-pdf/doi/10.1093/eurjpc/zwaf774/66006626/zwaf774.pdf |
Publication 17106
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Abstract
AIMS: Non-standard work schedules are becoming increasingly prevalent, with one in five workers participating in nightshifts. Whether working nightshifts is associated with cardiovascular-kidney-metabolic (CKM) outcomes, and whether chronotype or sleep duration moderate this association, remains unclear.</p>
METHODS: Our analysis is based on 96 365 UK Biobank participants (57% female, mean age 62 years), with information on employment history, tracking CKM incidence (cardiovascular diseases, chronic kidney diseases and/or type 2 diabetes) up to 2022. Cox proportional hazards models calculated hazard ratios (HR) adjusted for multiple potential confounders, and their 95% confidence intervals (CIs).</p>
RESULTS: With data on 5 967 incident cases, participants with over 20 years of night shift work had a significantly higher risk of CKM (HR=1.32 [95% CI, 1.20-1.45]) compared to day workers, after adjustment for confounders including sex, age, ethnicity, socioeconomic factors. Similarly, risk was higher than day workers among those working 8+ nightshifts per month (HR=1.32 [95% CI, 1.21-1.43]) and over 1200 lifetime nightshifts (HR=1.36 [95% CI, 1.25-1.48]); all Ptrend<0.001. The association between nightshift work and CKM risk was significantly modified by sleep duration, with higher risks among short sleepers (≤6 hours) (Pinteraction= 0.009, 0.031, and 0.017, respectively, for nightwork duration, intensity, and cumulative number of nights worked), but not by chronotype.</p>
CONCLUSION: Our findings reveal a dose-response relationship between night shift work and CKM disease, further amplified by short sleep. Future research should continue to adopt CKM conditions as a composite outcome and investigate further how sleep characteristics may modify the impact of night shift work.</p>
9 Authors
- Dat Thien Tran
- Susanne Strohmaier
- Magdalena Żebrowska
- Tianyi Huang
- Kyriaki Papantoniou
- Susan Redline
- Richa Saxena
- Martin K Rutter
- Eva Schernhammer
1 Application
| Application ID | Title |
|---|---|
| 48576 | A multi-polygenic score of clock resilience and its utility in predicting vulnerability to night work with regards to chronic disease risk (cardiovascular disease, type 2 diabetes, depression, breast) |
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