| Title: | Chronotype, Genetic Risk, Lifestyle, and Risk of Depression and Anxiety: A Prospective Cohort Study |
| Journal: | MedComm |
| Published: | 8 Apr 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41969631/ |
| DOI: | https://doi.org/10.1002/mco2.70736 |
Publication 18056
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Abstract
We aimed to evaluate associations of chronotype, genetic risk, and lifestyle with depression and anxiety. A total of 242,391 participants without anxiety and depression at baseline in UK Biobank were included. During a total of 3,393,260.1 and 1,371,872.8 person-years follow-up, we found 11,824 (4.88%) incident depression and 10,051 (4.15%) incident anxiety cases, respectively. Compared with definite morning group, individuals with intermediate (HR = 1.09, 95% CI = 1.04-1.13) and definite evening chronotype (HR = 1.45, 95% CI = 1.36-1.55) have higher risks of depression, and individuals with definite evening chronotype (HR = 1.27, 95% CI = 1.18-1.37) have a higher risk of anxiety. We found joint association between chronotype and genetic risk, those with high genetic risk and definite evening chronotype had the highest risk of depression (HR = 2.01, 95% CI = 1.81-2.23) and anxiety (HR = 1.40, 95% CI = 1.24-1.58). We also found joint association between chronotype and lifestyle, those with least healthy lifestyle and definite evening chronotype had the highest risk of depression (HR = 1.99, 95% CI = 1.65-2.40) and anxiety (HR = 1.69, 95% CI = 1.36-2.10). Individuals with evening chronotype are associated with higher risks of depression and anxiety.</p>
5 Authors
- Dongming Wang
- Zhonghe Shao
- Zhaomin Chen
- Xingjie Hao
- Wenzhen Li
1 Application
| Application ID | Title |
|---|---|
| 88159 | Fine-mapping, genetic correlation and genetic risk prediction for complex traits in different populations |
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