| Title: | Associations of urban heat island and its metabolomic profiles with all-cause and cause-specific mortality in middle-aged and older adults |
| Journal: | Ecotoxicology and Environmental Safety |
| Published: | 24 Mar 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41881869/ |
| DOI: | https://doi.org/10.1016/j.ecoenv.2026.120062 |
Publication 18223
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Abstract
OBJECTIVES: To investigate associations between urban heat island (UHI) exposure and mortality outcomes in urban residents, and to identify metabolic pathways mediating these relationships.</p>
METHODS: This prospective cohort study included 233,137 urban-dwelling middle-aged and older adults from the UK Biobank between 2006 and 2010. UHI exposure was estimated using satellite-derived land surface temperature data. Mortality outcomes were identified through national death registry records. Cox proportional hazards models assessed associations between long-term UHI exposure and mortality risk. Elastic net regression identified key metabolites related to exposure, followed by mediation analyses to quantify their mechanistic contributions and interaction analyses to examine how they modify the UHI-mortality relationship.</p>
RESULTS: Long-term UHI exposure was significantly associated with increased risk of all-cause mortality (HR: 1.05, 95% CI: 1.04-1.06), with the strongest associations observed for endocrine system diseases (HR: 1.08, 95% CI: 1.06-1.11) and respiratory diseases (HR: 1.08, 95% CI: 1.06-1.10). Glucose emerged as the strongest mediator, explaining 31.7% of the UHI effect on all-cause mortality. Interaction analyses revealed that metabolite levels modified UHI-mortality associations, particularly for endocrine diseases.</p>
CONCLUSIONS: UHI exposure significantly increases mortality risk among urban residents, with glucose and lipid serving as key biological mediators. These findings emphasize the importance of integrating climate resilience into urban planning and highlight potential targets for interventions to protect vulnerable populations from heat-related health impacts.</p>
15 Keywords
- Aged
- Cause of Death
- Cities
- Environmental Exposure
- Female
- Hot Temperature
- Humans
- Male
- Metabolome
- Metabolomics
- Middle Aged
- Mortality
- Prospective Studies
- United Kingdom
- Urban Population
9 Authors
- Jiahui Qiu
- Hao Zheng
- Jiawei Gu
- Lan Wu
- Ziyang Gong
- Yuewei Ling
- Jinjun Ran
- Mu He
- Hao Sun
1 Application
| Application ID | Title |
|---|---|
| 99001 | Gene-environment interaction analysis on age-related diseases |
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