| Title: | Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model |
| Journal: | Nature Genetics |
| Published: | 3 Feb 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41634413/ |
| DOI: | https://doi.org/10.1038/s41588-025-02486-7 |
| URL: | https://www.nature.com/articles/s41588-025-02486-7.pdf |
Publication 18387
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Abstract
We introduce mvSuSiE, a multitrait fine-mapping method, to identify putative causal variants from genetic association data (individual-level or summary). mvSuSiE learns patterns of shared genetic effects from data, and exploits these patterns to improve power to identify causal single nucleotide polymorphisms (SNPs). Comparisons on simulated data show that mvSuSiE is competitive in speed, power and precision with existing multitrait methods, and uniformly improves over single-trait fine-mapping (Sum of Single Effects) performed separately for each trait. We applied mvSuSiE to jointly fine-map 16 blood cell traits using data from the UK Biobank. By jointly analyzing traits and modeling heterogeneous effect-sharing patterns, we identified a substantially larger number of causal SNPs (>3,000) than single-trait fine-mapping and achieved narrower credible sets. mvSuSiE also more comprehensively characterized how genetic variants affect blood cell traits; 68% of causal SNPs showed significant effects across more than one blood cell type.</p>
8 Keywords
- Chromosome Mapping
- Computer Simulation
- Genome-Wide Association Study
- Humans
- Models, Genetic
- Phenotype
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
5 Authors
- Yuxin Zou
- Peter Carbonetto
- Dongyue Xie
- Gao Wang
- Matthew Stephens
1 Application
| Application ID | Title |
|---|---|
| 27386 | Augmenting data-driven discovery of disease risk genes using multivariate and integrative approaches to genome-wide association analysis |
Enabling scientific discoveries that improve human health