| Title: | Associations of physical activity and sedentary behaviors with mortality: An observational analysis and Mendelian randomization study |
| Journal: | Geriatric Nursing |
| Published: | 23 Jan 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41579440/ |
| DOI: | https://doi.org/10.1016/j.gerinurse.2026.103834 |
Publication 18493
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Abstract
BACKGROUND: To investigate the associations of physical activity (PA) and sedentary behavior (SB) with the risk of mortality using observational and Mendelian randomization (MR) designs.</p>
METHODS: In a prospective cohort study based on UK Biobank, data on PA and SB were collected and categorized as three mutually exclusive groups. Multivariable-adjusted Cox models and two-sample MR analysis were performed.</p>
RESULTS: Compared with low total PA (TPA), intermediate and high TPA were associated with a decreased risk of all-cause and cardiovascular disease (CVD) mortality. Compared with low levels, high total sitting time and television viewing time were associated with increased risk of all-cause and CVD mortality. The two-sample MR analysis indicated no causal relationship between genetic predispositions to PA/SB and mortality.</p>
CONCLUSIONS: Although PA was associated with a lower risk, prolonged sitting time was associated with an increased risk of all-cause and CVD mortality, two-sample MR did not support a causal effect.</p>
20 Authors
- Menglin Han
- Yudun Qu
- Muhui Zeng
- Ziqi Gu
- Yan Zhang
- Tianxiang Fan
- Qian Yang
- Zhiqiang Wang
- Peichun Gao
- Shibo Chen
- Kai Fu
- David J Hunter
- Shuai He
- Lixin Zhu
- Qing Wang
- Lizi Wang
- Hongbo Guo
- Changhai Ding
- Kangling Wang
- Zhaohua Zhu
1 Application
| Application ID | Title |
|---|---|
| 67654 | Genetic risk factors, environmental factors, and the gene-environment interactions in osteoarthritis |
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