| Title: | Dietary Index for Gut Microbiota, Plasma Metabolic Signature, and Risk of All-Cause and Cardiovascular Disease Mortality |
| Journal: | Endocrinology and Metabolism |
| Published: | 13 Jul 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42438999/ |
| DOI: | https://doi.org/10.3803/enm.2025.2787 |
| URL: | https://www.e-enm.org/upload/pdf/enm-2025-2787.pdf |
Publication 20288
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Background: The dietary index for gut microbiota (DI-GM) and its associations with mortality risk, as well as the underlying mechanisms, remain underexplored. We aimed to investigate the associations among DI-GM, a corresponding metabolic signature, and all-cause and cardiovascular disease (CVD) mortality.</p>
Methods: We analysed two cohort studies including 170,575 participants from the United Kingdom (UK) Biobank and 26,651 participants from the United States (US) National Health and Nutrition Examination Survey. We calculated DI-GM using 24-hour dietary recall questionnaire data and derived a corresponding metabolic signature using an elastic net regression model. Associations were assessed using Cox proportional hazards regression.</p>
Results: Participants in the highest DI-GM group had a lower risk of all-cause mortality (hazard ratio [HR], 0.86, P<0.001 in the UK cohort; HR, 0.79, P<0.001 in the US cohort) and CVD mortality (HR, 0.79, P=0.013 in the UK cohort; HR, 0.68, P=0.007 in the US cohort) than those in the lowest group. Both overall DI-GM and foods beneficial for gut microbiota were inversely associated with mortality risk in a dose-response manner. We identified a DI-GM metabolic signature comprising 124 metabolites in the UK cohort (r=0.25, P<2.2×10-16); this signature was associated with the risk of all-cause mortality (HR, 0.68, P<0.001) and CVD mortality (HR, 0.65, P=0.003) and explained 52.60% of the association between DI-GM and all-cause mortality.</p>
Conclusion: We identified a close connection between DI-GM, its metabolic signature, and mortality outcomes, highlighting the potential benefits of dietary patterns that support gut microbiota health for longevity.</p>
13 Authors
- Yingxin Liao
- Yuqing Deng
- Chao Yu
- Yuxiang Huang
- Beixuan Sun
- Qiaoqiao Yang
- Shijia Wang
- Peiting Zhang
- Mengyu Zhou
- Ailan Chen
- Wenhua Ling
- Xu Chen
- Hongliang Xue
2 Applications
| Application ID | Title |
|---|---|
| 76670 | Nutritional and lifestyle influences on the risk and outcome of different metabolic dysfunction-associated fatty liver disease (MAFLD) subtypes |
| 420999 | Dissecting the environmental, genetic and clinical determinants and their interactions on chronic diseases and its underlying mechanisms |
Enabling scientific discoveries that improve human health