| Title: | Risk of Inflammatory Bowel Disease Following Hospital-Treated Infections and Modulatory Role of Host Genetics to Support a Multi-Hit Pathogenesis Model |
| Journal: | Advanced Science |
| Published: | 13 Jul 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42439363/ |
| DOI: | https://doi.org/10.1002/advs.76509 |
Publication 20290
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Abstract
Infectious diseases can cause lasting immune disturbances, but whether they contribute to later inflammatory bowel disease (IBD) is unclear. Hospital-treated infections may be especially informative because they reflect substantial immune challenge, yet their relation to IBD risk and the role of host genetics remain poorly defined. It examines hospital-treated infections and incident IBD in a prospective cohort and integrates gene-environment interaction analyses to identify susceptibility pathways and develop a post-infection risk score. Hospital-treated infections of multiple pathogen types and sites were associated with higher subsequent IBD risk. This association is stronger in carriers of immune-related risk variants, with Crohn's disease linked mainly to innate immune and autophagy pathways and ulcerative colitis to JAK-STAT, T-cell differentiation, and chemokine signaling. An Infection IBD Score based on 44 immune-related genes stratified post-infection risk. These findings support infections as triggers of IBD in genetically susceptible individuals and highlight a potential tool for risk stratification.</p>
17 Authors
- Haiming Zhuang
- Lintao Dan
- Xin Xiang
- Xixian Ruan
- Shuai Yuan
- Jialu Yao
- Jiawei Geng
- Jonas F. Ludvigsson
- Tian Fu
- Candida Abreu
- Laurent Peyrin-Biroulet
- Xue Li
- Yi Xiao
- Fernando Magro
- Xiaoyan Wang
- Jing Sun
- Jie Chen
1 Application
| Application ID | Title |
|---|---|
| 232231 | Deciphering the impact of environmental determinants on digestive system disease and other chronic diseases based on the multi-omic data |
Enabling scientific discoveries that improve human health