| Title: | Age-dependent convergence of kidney stone incidence rates between male and female populations |
| Journal: | Scientific Reports |
| Published: | 7 Aug 2026 |
| DOI: | https://doi.org/10.1038/s41598-026-63938-6 |
| URL: | https://www.nature.com/articles/s41598-026-63938-6_reference.pdf |
Publication 21042
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Abstract
Kidney stone disease has historically shown higher incidence in men than women, but emerging evidence suggests this gap narrows with age. Using the UK Biobank, we analyzed 494,745 stone-free participants from 2010 to 2022. During follow-up, 5,614 incident cases were identified, with men consistently at higher risk. However, the male-to-female relative risk declined significantly with advancing age, decreasing 0.86%-1.34% per year (Y = 3.49-0.02x). This trend was evident in both single-year and 5-year stratifications, while no significant temporal change was observed across calendar years. Our findings indicate a progressive convergence in stone risk between sexes, underscoring the importance of incorporating age- and sex-specific considerations into prevention and management strategies for kidney stone disease.</p>
9 Authors
- Cheng-Yu T. Huang
- Kazumi Taguchi
- Fredrick R. Schumacher
- Donald Bodner
- Felipe Ignacio Pauchard
- Jose Antonio Salvado
- Kyle Wood
- Marshall Stoller
- Chen-Han W. Wu
1 Application
| Application ID | Title |
|---|---|
| 87480 | Genetic and environment analyses for urological conditions |
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