| Title: | Differential associations of PM2.5 constituents on different stages of CKD: The role of lifestyle, genetic risk, and biological age acceleration |
| Journal: | Environmental Chemistry and Ecotoxicology |
| Published: | 1 Aug 2026 |
| DOI: | https://doi.org/10.1016/j.enceco.2026.08.009 |
Publication 21103
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Abstract
Background To evaluate the associations of fine particulate matter (PM2.5) and its constituents with the risk of different stages of chronic kidney disease (CKD), as well as the modification by lifestyle and genetic risk and the mediation by accelerated biological aging. Methods A total of 448,282 participants without CKD were included in this study. Bilinear interpolation approach was utilized to assess annual levels of PM2.5 and constituents. Cox proportional hazard model was utilized to evaluate the associations of PM2.5 constituents with risks of CKD stages. We examined the potential modifying role of lifestyle and genetic risk. Mediation analyses were conducted to investigate the mediation role of biological aging in PM2.5 constituents-CKD stages associations. Results During a median follow-up of 13.66 years, 17,724 participants developed incident CKD. Long-term exposure to PM2.5 and constituents was associated with increased CKD risk in different stages, with hazard ratios [HRs (95% confidence intervals, CIs)] ranging from 1.05 (1.03, 1.08) for elemental carbon (EC)-CKD association to 1.25 (1.12, 1.40) for Organic matter (OM) -CKD stage 5 association. Additive interactions of PM2.5, sulfate, OM, and EC with lifestyle were observed in relation to CKD risk. Biological aging acceleration served as a mediator in PM2.5 constituents-CKD stages relationships; the mediation proportions ranged from 4.56% (sulfate-CKD stage 1-2 association) to 28.32% (sulfate-CKD stage 5 association). Discussion Long-term exposure to PM2.5 and its constituents might increase the risk of CKD in different stages, especially in those with unhealthier lifestyles, with biological aging involved in the mechanisms potentially.</p>
10 Authors
- Peng Hu
- Shengtao Wei
- Lan Chen
- Fei Tian
- Chongjian Wang
- Manting Rao
- Zhenhe Huang
- Xiangling Wang
- Hualiang Lin
- Xiaojie Wang
1 Application
| Application ID | Title |
|---|---|
| 69550 | Identifying the potential effects of environmental and other healthcare related factors influencing health outcomes, mediated by genetic variances |
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