| Title: | Wearable device-measured sedentary behaviour, physical activity, and incident symptomatic peripheral artery disease: a prospective cohort study of 87,490 adults |
| Journal: | Archives of Physical Medicine and Rehabilitation |
| Published: | 31 Jul 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42537768/ |
| DOI: | https://doi.org/10.1016/j.apmr.2026.07.023 |
Publication 21110
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Abstract
OBJECTIVE: To investigate the associations of device-measured sedentary behaviour (SB), light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) with incident symptomatic peripheral artery disease (PAD).</p>
DESIGN: Cohort study.</p>
SETTING: A community-based volunteer sample recruited across the United Kingdom.</p>
PARTICIPANTS: A total of 87,490 adults without cardiovascular disease who had valid wrist-worn accelerometer data and met the study eligibility criteria.</p>
INTERVENTIONS: Not applicable.</p>
MAIN OUTCOME MEASURE(S): Incident symptomatic PAD identified during follow-up.</p>
RESULTS: Over a median follow-up of 7.9 years, 569 participants developed symptomatic PAD. Participants in the highest SB tertile had a 43% increased risk of symptomatic PAD [hazard ratio (HR): 1.43, 95% confidence interval (CI): 1.16 to 1.76] compared to those in the lowest tertile. In contrast, higher MVPA was associated with lower symptomatic PAD risk, whereas LPA showed no significant association. All behaviours showed a significant nonlinear association with symptomatic PAD (all P-non-linear <0.05). Joint analysis revealed the lowest symptomatic PAD risk among participants with both low SB and high MVPA, with no significant interaction observed. Isotemporal substitution analyses suggested that replacing SB with MVPA was associated with the greatest estimated reduction in symptomatic PAD risk.</p>
CONCLUSIONS: Higher SB is independently associated with higher symptomatic PAD risk, whereas greater MVPA was associated with lower risk. These findings underscore the potential importance of considering both MVPA promotion and sedentary time reduction in future PAD prevention.</p>
12 Authors
- Xiaolong Zhang
- Xiaoya Sun
- Xiwang Mao
- Chongyue Zhang
- Jiejun Zhang
- Jingwei Ren
- Tianyuan Wang
- Zhenao Zhang
- Bowen Yin
- Weiwei Yang
- Jingyi Ren
- Yuxia Ma
1 Application
| Application ID | Title |
|---|---|
| 471488 | Association between factors influencing the life course and the occurrence and progression of chronic noncommunicable diseases |
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