| Title: | Proteomic signatures reveal stage-specific progression across gastrointestinal-neuropsychiatric comorbidity: a deep learning and multi-state trajectory analysis |
| Journal: | Scientific Reports |
| Published: | 1 Aug 2026 |
| DOI: | https://doi.org/10.1038/s41598-026-64711-5 |
| URL: | https://www.nature.com/articles/s41598-026-64711-5_reference.pdf |
Publication 21252
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Gastrointestinal and neuropsychiatric disorders frequently co-occur, but their shared plasma-proteomic associations across disease stages remain unclear. We analyzed 2,920 plasma proteins in 52,953 UK Biobank participants across seven gastrointestinal and nine neuropsychiatric outcomes during a median follow-up of 13.3 years. Proteome-wide Cox analyses identified shared proteins associated with outcomes in both systems. In a strictly nested analysis of 45,811 participants without a study endpoint at baseline, training-only screening identified 198 proteins for CoMorbNet feature prioritization. The cross-system comorbidity model achieved an AUC of 0.717 in a nested held-out validation analysis. Compared with the low-score tertile, the high-score tertile was associated with higher hazards (HRs) across all five disease transitions (HRs, 1.54-2.15; all P < 0.001). Shared proteins were enriched in immune-related pathways. These findings identify stage-specific proteomic patterns associated with gastrointestinal-neuropsychiatric comorbidity, but external validation is required before clinical use.</p>
11 Authors
- Xiaohua Ye
- Zhenhe Jin
- Tianyu Zhou
- Zhijian Zhao
- Chunmin Lou
- Chengwei Xu
- Kexin Ye
- Yandong Li
- Yufan Wang
- Chaohui Yu
- Zhe Shen
1 Application
| Application ID | Title |
|---|---|
| 176969 | Gut-brain connections from magnetic resonance images |
Enabling scientific discoveries that improve human health