| Title: | Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan |
| Journal: | Nature Communications |
| Published: | 31 Mar 2016 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/27029810/ |
| DOI: | https://doi.org/10.1038/ncomms11174 |
| URL: | https://www.nature.com/articles/ncomms11174.pdf |
| Citations: | 92 (22 in last 2 years) as of 8 Aug 2024 |
Publication 264
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Abstract
Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that common variants near the apolipoprotein E and nicotinic acetylcholine receptor subunit alpha 5 genes are associated with lifespan. The effects are strongly sex and age dependent, with APOE ɛ4 differentially influencing maternal lifespan (P=4.2 × 10−15, effect −1.24 years of maternal life per imputed risk allele in parent; sex difference, P=0.011), and a locus near CHRNA3/5 differentially affecting paternal lifespan (P=4.8 × 10−11, effect −0.86 years per allele; sex difference P=0.075). Rare homozygous carriers of the risk alleles at both loci are predicted to have 3.3-3.7 years shorter lives.</p>
6 Authors
- Peter K. Joshi
- Krista Fischer
- Katharina E. Schraut
- Harry Campbell
- Tõnu Esko
- James F. Wilson
1 Application
| Application ID | Title |
|---|---|
| 8304 | Genetics of human lifespan ? heritability, association and prediction |
Enabling scientific discoveries that improve human health