| Title: | ISSLS Prize in Clinical Science 2020. Examining causal effects of body mass index on back pain: a Mendelian randomization study |
| Journal: | European Spine Journal |
| Published: | 3 Dec 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31797139/ |
| DOI: | https://doi.org/10.1007/s00586-019-06224-6 |
| URL: | https://kclpure.kcl.ac.uk/ws/files/120699869/clean_pre_print_posting_ALL_FILES_Mendelian_Randomization_BMI_back_pain_12.15.2019.pdf |
| Citations: | 36 (19 in last 2 years) as of 8 Aug 2024 |
Publication 3209
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Abstract
PurposeMeasures of body fat accumulation are associated with back pain, but a causal association is unclear. We hypothesized that BMI would have causal effects on back pain. We conducted a two-sample Mendelian randomization (MR) study to assess the causal effect of body mass index (BMI) on the outcomes of (1) back pain and (2) chronic back pain (duration > 3 months).</p>
MethodsWe identified genetic instrumental variables for BMI (n = 60 variants) from a meta-analysis of genome-wide association studies (GWAS) conducted by the Genetic Investigation of ANthropometric Traits consortium in individuals of European ancestry (n = 322,154). We conducted GWAS of back pain and chronic back pain (n = 453,860) in a non-overlapping sample of individuals of European ancestry. We used inverse-variance weighted (IVW) meta-analysis as the primary method to estimate causal effects.</p>
ResultsThe IVW analysis showed evidence supporting a causal association of BMI on back pain, with a 1-standard deviation (4.65 kg/m2) increase in BMI conferring 1.15 times the odds of back pain (95% confidence interval [CI]: 1.06-1.25, p = 0.001]; effects were directionally consistent in secondary analysis and sensitivity analyses. The IVW analysis supported a causal association of BMI on chronic back pain (OR 1.20 per 1 SD deviation increase in BMI [95% CI 1.09-1.32; p = 0.0002]), and effects were directionally consistent in secondary analysis and sensitivity analyses.ConclusionIn this first MR study of BMI and back pain, we found a significant causal effect of BMI on both back pain and chronic back pain.Graphic abstractThese slides can be retrieved under Electronic Supplementary Material.</p>
7 Keywords
- Awards and Prizes
- Back Pain
- Body Mass Index
- Genome-Wide Association Study
- Humans
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
6 Authors
- Elizaveta E. Elgaeva
- Yakov Tsepilov
- Maxim B. Freidin
- Frances M. K. Williams
- Yurii Aulchenko
- Pradeep Suri
1 Application
| Application ID | Title |
|---|---|
| 18219 | Genetic and epidemiological analyses of low back pain |
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