| Title: | Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction |
| Journal: | Scientific Reports |
| Published: | 8 Nov 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34750467/ |
| DOI: | https://doi.org/10.1038/s41598-021-01291-6 |
| URL: | https://www.nature.com/articles/s41598-021-01291-6.pdf |
| Citations: | 8 (5 in last 2 years) as of 8 Aug 2024 |
Publication 4468
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Abstract
Asthma is a complex disease that is reportedly associated with insomnia. However, the causal directionality of this association is still unclear. We used asthma and insomnia-associated single nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) summary statistics to test the causal directionality between insomnia and asthma via Mendelian randomization (MR) analysis. We also performed a cross-trait meta-analysis using UK Biobank GWAS summary statistics and a gene-environment interaction study using data from UK Biobank. The interaction of genetic risk score for asthma (GRSasthma) with insomnia on asthma was tested by logistic regression. Insomnia was a risk factor for the incidence of asthma, as revealed by three different methods of MR analysis. However, asthma did not act as a risk factor for insomnia. The cross-trait meta-analysis identified 28 genetic loci shared between asthma and insomnia. In the gene-environment interaction study, GRSasthma interacted with insomnia to significantly affect the risk of asthma. The results of this study highlight the importance of insomnia as a risk factor of asthma, and warrant further analysis of the mechanism through which insomnia affects the risk of asthma.</p>
10 Authors
- Dong Jun Kim
- Tae-Woong Ha
- Hae Un Jung
- Eun Ju Baek
- Won Jun Lee
- Han Kyul Kim
- Ji-One Kang
- Sungho Won
- Ji Eun Lim
- Bermseok Oh
Enabling scientific discoveries that improve human health