| Title: | Lipoprotein(a) and SARS-CoV-2 infections: Susceptibility to infections, ischemic heart disease and thromboembolic events |
| Journal: | Journal of Internal Medicine |
| Published: | 29 Oct 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34096654/ |
| DOI: | https://doi.org/10.1111/joim.13338 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/joim.13338 |
| Citations: | 27 (12 in last 2 years) as of 8 Aug 2024 |
Publication 5329
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Abstract
BACKGROUND: Comorbidities including ischemic heart disease (IHD) worsen outcomes after SARS-CoV-2 infections. High lipoprotein(a) [Lp(a)] concentrations are a strong risk factor for IHD and possibly for thromboembolic events. We therefore evaluated whether SARS-CoV-2 infections modify the risk of high Lp(a) concentrations for IHD or thromboembolic events during the first 8.5 months follow-up of the pandemic.</p>
METHOD: Cohort study using data from the UK Biobank during the SARS-CoV-2 pandemic. Baseline Lp(a) was compared between SARS-CoV-2 positive patients and the population controls.</p>
RESULTS: SARS-CoV-2 positive patients had Lp(a) concentrations similar to the population controls. The risk for IHD increased with higher Lp(a) concentrations in both, the population controls (n = 435,104) and SARS-CoV-2 positive patients (n = 6937). The causality of the findings was supported by a genetic risk score for Lp(a). A SARS-CoV-2 infection modified the association with a steeper increase in risk for infected patients (interaction p-value = 0.03). Although SARS-CoV-2 positive patients had a five-times higher frequency of thromboembolic events compared to the population controls (1.53% vs. 0.31%), the risk was not influenced by Lp(a).</p>
CONCLUSIONS: SARS-CoV-2 infections enforce the association between high Lp(a) and IHD but the risk for thromboembolic events is not influenced by Lp(a).</p>
7 Authors
- Silvia Di Maio
- Claudia Lamina
- Stefan Coassin
- Lukas Forer
- Reinhard Würzner
- Sebastian Schönherr
- Florian Kronenberg
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