| Title: | Speech-in-noise hearing impairment is associated with an increased risk of incident dementia in 82,039 UK Biobank participants |
| Journal: | Alzheimer's & Dementia |
| Published: | 21 Jul 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34288382/ |
| DOI: | https://doi.org/10.1002/alz.12416 |
| URL: | https://ora.ox.ac.uk/objects/uuid:39416087-e630-43ad-b99e-f02ad0777079/files/rv405s976g |
| Citations: | 44 (32 in last 2 years) as of 8 Aug 2024 |
Publication 5774
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Abstract
INTRODUCTION: Little is known about the association between speech-in-noise (SiN) hearing impairment and dementia.</p>
METHODS: In 82,039 dementia-free participants aged ≥60 years were selected from the UK Biobank. Cox proportional-hazards models were used to investigate whether SiN hearing impairment is associated with an increased risk of incident dementia.</p>
RESULTS: Over 11 years of follow-up (median = 10.1), 1285 participants developed dementia. Insufficient and poor SiN hearing were associated with a 61% (hazard ratio [HR] = 1.61, 95% confidence [CI] 1.41-1.84) and 91% (HR = 1.91, 95% CI 1.55-2.36) increased risk of developing dementia, respectively, compared to normal SiN hearing. The association remained similar when restricting to follow-up intervals of ≤3, >3 to <6, >6 to <9, and >9 years. There was limited evidence for mediation through depressive symptoms and social isolation.</p>
DISCUSSION: SiN hearing impairment is independently associated with incident dementia, providing further evidence for hearing impairment as a potential modifiable dementia risk factor.</p>
8 Keywords
- Biological Specimen Banks
- Dementia
- Hearing
- Hearing Loss
- Humans
- Risk Factors
- Speech
- United Kingdom
4 Authors
- Jonathan S. Stevenson
- Lei Clifton
- Elżbieta Kuźma
- Thomas J. Littlejohns
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