| Title: | Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations |
| Journal: | Circulation Genomic and Precision Medicine |
| Published: | 16 Jul 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34270325/ |
| DOI: | https://doi.org/10.1161/circgen.120.003288 |
| URL: | https://www.ahajournals.org/doi/pdf/10.1161/CIRCGEN.120.003288 |
| Citations: | 8 (4 in last 2 years) as of 8 Aug 2024 |
Publication 5785
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Abstract
BACKGROUND: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. We hypothesized that SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia.</p>
METHODS: Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near CHREBP were considered. SSB consumption was estimated from validated questionnaires, and participants were grouped by their estimated intake.</p>
RESULTS: In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16-3.07] mg/dL per allele; P<0.0001), but not significantly among the lowest SSB consumers (P=0.81; PDiff <0.0001). Similar results were observed for 2 additional variants (rs35709627 and rs71556736). For triglyceride, rs55673514 was positively associated with triglyceride concentrations only among the highest SSB consumers (β, 0.06 [95% CI, 0.02-0.09] ln-mg/dL per allele, P=0.001) but not the lowest SSB consumers (P=0.84; PDiff=0.0005).</p>
CONCLUSIONS: Our results identified genetic variants in the CHREBP locus that may protect against SSB-associated reductions in HDL-C and other variants that may exacerbate SSB-associated increases in triglyceride concentrations. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00005133, NCT00005121, NCT00005487, and NCT00000479.</p>
11 Keywords
- Adult
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Cholesterol, HDL
- Female
- Humans
- Male
- Meta-Analysis as Topic
- Middle Aged
- Polymorphism, Single Nucleotide
- Sugar-Sweetened Beverages
- Triglycerides
56 Authors
- Danielle E. Haslam
- Gina M. Peloso
- Melanie Guirette
- Fumiaki Imamura
- Traci M. Bartz
- Achilleas N. Pitsillides
- Carol A. Wang
- Ruifang Li-Gao
- Jason M. Westra
- Niina Pitkänen
- Kristin L. Young
- Mariaelisa Graff
- Alexis C. Wood
- Kim V.E. Braun
- Jian'an Luan
- Mika Kähönen
- Jessica C. Kiefte-de Jong
- Mohsen Ghanbari
- Nathan Tintle
- Rozenn N. Lemaitre
- Dennis O. Mook-Kanamori
- Kari North
- Mika Helminen
- Yasmin Mossavar-Rahmani
- Linda Snetselaar
- Lisa W. Martin
- Jorma S. Viikari
- Wendy H. Oddy
- Craig E. Pennell
- Frits R. Rosendall
- M. Arfan Ikram
- Andre G Uitterlinden
- Bruce M. Psaty
- Dariush Mozaffarian
- Jerome I. Rotter
- Kent D. Taylor
- Terho Lehtimäki
- Olli T. Raitakari
- Kara A. Livingston
- Trudy Voortman
- Nita G. Forouhi
- Nick J. Wareham
- Renée de Mutsert
- Steven S. Rich
- JoAnn E. Manson
- Samia Mora
- Paul M. Ridker
- Jordi Merino
- James B. Meigs
- Hassan S. Dashti
- Daniel I. Chasman
- Alice H. Lichtenstein
- Caren E. Smith
- Josée Dupuis
- Mark A. Herman
- Nicola M. McKeown
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