| Title: | Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection |
| Journal: | Nature Genetics |
| Published: | 11 Sep 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28892061/ |
| DOI: | https://doi.org/10.1038/ng.3954 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133304 |
| Citations: | 436 (123 in last 2 years) as of 8 Aug 2024 |
Publication 727
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Abstract
Steven Gazal, Alkes Price and colleagues extend stratified LD score regression to continuous annotations. They analyze summary statistics from 56 complex diseases and traits and find that SNPs with low levels of linkage disequilibrium have larger per-SNP heritability, consistent with the action of negative selection on deleterious variants that affect complex traits.</p>
11 Authors
- Steven Gazal
- Hilary K Finucane
- Nicholas A Furlotte
- Po-Ru Loh
- Pier Francesco Palamara
- Xuanyao Liu
- Armin Schoech
- Brendan Bulik-Sullivan
- Benjamin M Neale
- Alexander Gusev
- Alkes L Price
1 Application
| Application ID | Title |
|---|---|
| 16549 | Components of heritability in a UK Biobank cohort |
Enabling scientific discoveries that improve human health