| Title: | Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets |
| Journal: | Nature Genetics |
| Published: | 6 Feb 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28166213/ |
| DOI: | https://doi.org/10.1038/ng.3787 |
| URL: | https://europepmc.org/articles/pmc5326681?pdf=render |
| Citations: | 258 (42 in last 2 years) as of 8 Aug 2024 |
Publication 740
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Louise Wain, Ian Hall, Martin Tobin and colleagues report genome-wide association analyses of lung function, identifying 43 new signals associated with one or more lung function traits. A genetic risk score derived from these results was significantly associated with risk for chronic obstructive pulmonary disease in independent populations.</p>
106 Authors
- Louise V Wain
- Nick Shrine
- María Soler Artigas
- A Mesut Erzurumluoglu
- Boris Noyvert
- Lara Bossini-Castillo
- Ma'en Obeidat
- Amanda P Henry
- Michael A Portelli
- Robert J Hall
- Charlotte K Billington
- Tracy L Rimington
- Anthony G Fenech
- Catherine John
- Tineka Blake
- Victoria E Jackson
- Richard J Allen
- Bram P Prins
- Archie Campbell
- David J Porteous
- Marjo-Riitta Jarvelin
- Matthias Wielscher
- Alan L James
- Jennie Hui
- Nicholas J Wareham
- Jing Hua Zhao
- James F Wilson
- Peter K Joshi
- Beate Stubbe
- Rajesh Rawal
- Holger Schulz
- Medea Imboden
- Nicole M Probst-Hensch
- Stefan Karrasch
- Christian Gieger
- Ian J Deary
- Sarah E Harris
- Jonathan Marten
- Igor Rudan
- Stefan Enroth
- Ulf Gyllensten
- Shona M Kerr
- Ozren Polasek
- Mika Kähönen
- Ida Surakka
- Veronique Vitart
- Caroline Hayward
- Terho Lehtimäki
- Olli T Raitakari
- David M Evans
- A John Henderson
- Craig E Pennell
- Carol A Wang
- Peter D Sly
- Emily S Wan
- Robert Busch
- Brian D Hobbs
- Augusto A Litonjua
- David W Sparrow
- Amund Gulsvik
- Per S Bakke
- James D Crapo
- Terri H Beaty
- Nadia N Hansel
- Rasika A Mathias
- Ingo Ruczinski
- Kathleen C Barnes
- Yohan Bossé
- Philippe Joubert
- Maarten van den Berge
- Corry-Anke Brandsma
- Peter D Paré
- Don D Sin
- David C Nickle
- Ke Hao
- Omri Gottesman
- Frederick E Dewey
- Shannon E Bruse
- David J Carey
- H Lester Kirchner
- Stefan Jonsson
- Gudmar Thorleifsson
- Ingileif Jonsdottir
- Thorarinn Gislason
- Kari Stefansson
- Claudia Schurmann
- Girish Nadkarni
- Erwin P Bottinger
- Ruth J F Loos
- Robin G Walters
- Zhengming Chen
- Iona Y Millwood
- Julien Vaucher
- Om P Kurmi
- Liming Li
- Anna L Hansell
- Chris Brightling
- Eleftheria Zeggini
- Michael H Cho
- Edwin K Silverman
- Ian Sayers
- Gosia Trynka
- Andrew P Morris
- David P Strachan
- Ian P Hall
- Martin D Tobin
1 Application
| Application ID | Title |
|---|---|
| 648 | Common and rare genetic variants in respiratory health: the UK Biobank Lung Exome Variant Evaluation (UK BiLEVE) consortium |
Enabling scientific discoveries that improve human health