| Title: | Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7 |
| Journal: | Nature Genetics |
| Published: | 9 Jan 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28067910/ |
| DOI: | https://doi.org/10.1038/ng.3761 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289625 |
| Citations: | 153 (21 in last 2 years) as of 8 Aug 2024 |
Publication 7541
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Carl Anderson, Jeffrey Barrett and colleagues use whole-genome sequencing and imputation to explore the genetic architecture of inflammatory bowel disease. They identify a low-frequency missense variant in ADCY7 that doubles risk of ulcerative colitis and detect a burden of very rare, damaging missense variants in known Crohn's disease risk genes.</p>
30 Authors
- Yang Luo
- Katrina M de Lange
- Luke Jostins
- Loukas Moutsianas
- Joshua Randall
- Nicholas A Kennedy
- Christopher A Lamb
- Shane McCarthy
- Tariq Ahmad
- Cathryn Edwards
- Eva Goncalves Serra
- Ailsa Hart
- Chris Hawkey
- John C Mansfield
- Craig Mowat
- William G Newman
- Sam Nichols
- Martin Pollard
- Jack Satsangi
- Alison Simmons
- Mark Tremelling
- Holm Uhlig
- David C Wilson
- James C Lee
- Natalie J Prescott
- Charlie W Lees
- Christopher G Mathew
- Miles Parkes
- Jeffrey C Barrett
- Carl A Anderson
Enabling scientific discoveries that improve human health