| Title: | Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation |
| Journal: | Nature Genetics |
| Published: | 14 Nov 2016 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/27841878/ |
| DOI: | https://doi.org/10.1038/ng.3715 |
| URL: | https://europepmc.org/articles/pmc5370207?pdf=render |
| Citations: | 281 (66 in last 2 years) as of 8 Aug 2024 |
Publication 7544
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Abstract
Thomas Hoffmann, Neil Risch and colleagues use longitudinal electronic health records from almost 100,000 individuals to conduct genome-wide association studies for blood pressure measurements. They find new significant loci that replicate in independent cohorts and can double the variance explained by using multiple blood pressure data points.18 Keywords
- Adult
- Blood Pressure
- Cohort Studies
- Electronic Health Records
- Ethnicity
- Female
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Hypertension
- Longitudinal Studies
- Male
- Meta-Analysis as Topic
- Middle Aged
- Phenotype
- Polymorphism, Single Nucleotide
- Prevalence
9 Authors
- Thomas J Hoffmann
- Georg B Ehret
- Priyanka Nandakumar
- Dilrini Ranatunga
- Catherine Schaefer
- Pui-Yan Kwok
- Carlos Iribarren
- Aravinda Chakravarti
- Neil Risch
Enabling scientific discoveries that improve human health