| Title: | Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality |
| Journal: | Nature Genetics |
| Published: | 31 Oct 2016 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/27798624/ |
| DOI: | https://doi.org/10.1038/ng.3708 |
| URL: | https://qmro.qmul.ac.uk/xmlui/bitstream/123456789/25995/1/Eppinga%20Identification%20of%20genomic%20loci%202016%20Submitted.pdf |
| Citations: | 140 (27 in last 2 years) as of 8 Aug 2024 |
Publication 7546
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Abstract
Pim van der Harst and colleagues report a genome-wide association study for resting heart rate in individuals of European ancestry and identify 64 associated loci, 46 of which have not been previously reported. A genetic risk score constructed using the associated variants is significantly associated with increased mortality risk.13 Keywords
- Arrhythmias, Cardiac
- Female
- Genetic Loci
- Genetic Variation
- Genome-Wide Association Study
- Genomics
- Heart Rate
- Humans
- Male
- Middle Aged
- Rest
- Risk Factors
- Survival Rate
10 Authors
- Ruben N Eppinga
- Yanick Hagemeijer
- Stephen Burgess
- David A Hinds
- Kari Stefansson
- Daniel F Gudbjartsson
- Dirk J van Veldhuisen
- Patricia B Munroe
- Niek Verweij
- Pim van der Harst
Enabling scientific discoveries that improve human health