| Title: | Genetic footprints of assortative mating in the Japanese population |
| Journal: | Nature Human Behaviour |
| Published: | 22 Sep 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36138222/ |
| DOI: | https://doi.org/10.1038/s41562-022-01438-z |
| URL: | https://www.nature.com/articles/s41562-022-01438-z.pdf |
| Citations: | 10 (9 in last 2 years) as of 8 Aug 2024 |
Publication 7561
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Abstract
Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating partners. Detecting the evidence of AM has been challenging due to the lack of large-scale datasets that include phenotypic data on both partners, especially in populations of non-European ancestries. Gametic phase disequilibrium between trait-associated alleles is a signature of parental AM on a polygenic trait, which can be detected even without partner data. Here, using polygenic scores for 81 traits in the Japanese population using BioBank Japan Project genome-wide association studies data (n = 172,270), we found evidence of AM on the liability to type 2 diabetes and coronary artery disease, as well as on dietary habits. In cross-population comparison using United Kingdom Biobank data (n = 337,139) we found shared but heterogeneous impacts of AM between populations.11 Authors
- Kenichi Yamamoto
- Kyuto Sonehara
- Shinichi Namba
- Takahiro Konuma
- Hironori Masuko
- Satoru Miyawaki
- Yoichiro Kamatani
- Nobuyuki Hizawa
- Keiichi Ozono
- Loic Yengo
- Yukinori Okada
1 Application
| Application ID | Title |
|---|---|
| 47821 | Trans-ethnic GWAS meta-analysis and exploration of trait-relevant genetic architecture. |
Enabling scientific discoveries that improve human health