| Title: | Genetic map of regional sulcal morphology in the human brain from UK biobank data |
| Journal: | Nature Communications |
| Published: | 14 Oct 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36241887/ |
| DOI: | https://doi.org/10.1038/s41467-022-33829-1 |
| URL: | https://www.nature.com/articles/s41467-022-33829-1.pdf |
Publication 8120
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Genetic associations with macroscopic brain structure can provide insights into brain function and disease. However, specific associations with measures of local brain folding are largely under-explored. Here, we conducted large-scale genome- and exome-wide associations of regional cortical sulcal measures derived from magnetic resonance imaging scans of 40,169 individuals in UK Biobank. We discovered 388 regional brain folding associations across 77 genetic loci, with genes in associated loci enriched for expression in the cerebral cortex, neuronal development processes, and differential regulation during early brain development. We integrated brain eQTLs to refine genes for various loci, implicated several genes involved in neurodevelopmental disorders, and highlighted global genetic correlations with neuropsychiatric phenotypes. We provide an interactive 3D visualisation of our summary associations, emphasising added resolution of regional analyses. Our results offer new insights into the genetic architecture of brain folding and provide a resource for future studies of sulcal morphology in health and disease.18 Authors
- Benjamin B. Sun
- Stephanie J. Loomis
- Fabrizio Pizzagalli
- Natalia Shatokhina
- Jodie N. Painter
- Christopher N. Foley
- Megan E. Jensen
- Donald G. McLaren
- Sai Spandana Chintapalli
- Alyssa H. Zhu
- Daniel Dixon
- Tasfiya Islam
- Iyad Ba Gari
- Heiko Runz
- Sarah E. Medland
- Paul M. Thompson
- Neda Jahanshad
- Christopher D. Whelan
Enabling scientific discoveries that improve human health