| Title: | Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants |
| Journal: | The Journals of Gerontology Series A |
| Published: | 29 Nov 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38029284/ |
| DOI: | https://doi.org/10.1093/gerona/glad266 |
| Citations: | 4 (4 in last 2 years) as of 8 Aug 2024 |
Publication 8236
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Abstract
Previous researchers have tried to explore the association between folate/folic acid intake and dementia incidence, but the results remain controversial. We evaluated the associations of folate/folic acid supplementation alone and in combination with other B vitamins on dementia risk and brain structure. A total of 466 224 UK Biobank participants were investigated. Cox proportional hazards models were used to assess the associations between folate/folic acid supplementation status and the risk of Alzheimer's disease (AD) and vascular dementia (VD). Multivariable linear regression models were employed to evaluate the association between folate/folic acid supplementation status and brain structure. In the final model, folate/folic acid supplementation alone was significantly associated with a higher risk of AD (hazard ratio [HR] = 1.34, 95% confidence interval [CI] = 1.06-1.69, p = .015) and VD (HR = 1.61, 95% CI = 1.21-2.13, p = .001). Folate/folic acid supplementation alone was associated with a reduction in the hippocampus (β = -95.25 mm3, 95% CI = -165.31 to -25.19 mm3, p = .014) and amygdala (β = -51.85 mm3, 95% CI = -88.02 to -15.68 mm3, p = .012). The risk of AD and VD, as well as brain structure, in the group with combined folate/folic acid supplementation and other B vitamins did not show a statistically significant difference compared to the reference group (all p > .05). Folate/folic acid supplementation alone is significantly associated with a higher risk of AD and VD, as well as adverse alterations in brain structure. However, when combined with other B vitamins, these detrimental effects can be counteracted.</p>
8 Keywords
- Biological Specimen Banks
- Brain
- Dementia
- Dietary Supplements
- Folic Acid
- Humans
- UK Biobank
- Vitamin B Complex
7 Authors
- Yitong Ling
- Shiqi Yuan
- Xiaxuan Huang
- Shanyuan Tan
- Hongtao Cheng
- Anding Xu
- Jun Lyu
1 Application
| Application ID | Title |
|---|---|
| 76636 | Analysis of the influencing factors of dementia |
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