| Title: | Associations of Leg Length, Trunk Length, and Total Adult Height With Ménière's |
| Journal: | Ear & Hearing |
| Published: | 1 May 2015 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/25551408/ |
| DOI: | https://doi.org/10.1097/aud.0000000000000132 |
Publication 8410
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Abstract
OBJECTIVES: To investigate whether adverse intrauterine and/or childhood exposures, using established anthropometric measures (e.g., components of adult height, including total height, leg length, and trunk length) as a proxy for childhood exposures, are associated with self-reported Ménière's disease.</p>
DESIGN: Cross-sectional data from the UK Biobank were used to compare 1,327 self-reported Ménière's cases with 479,500 controls. The authors used logistic regression models to investigate the relation of Ménière's disease with the components of adult height. Models were adjusted for a range of potential confounders including age, sex, body mass index, ethnicity, type 2 diabetes, coronary heart disease, and socioeconomic status.</p>
RESULTS: In the UK Biobank, Ménière's was inversely associated with overall stature (odds ratio [OR] per standard deviation increase in height, 0.87; 95% confidence interval [CI], 0.80-0.94) and leg length (OR, 0.88; 95% CI, 0.82-0.94) in fully adjusted models. No association was noted in adjusted models with trunk length (OR, 0.94; 95% CI, 0.88-1.01).</p>
CONCLUSIONS: The specific association between leg length, a potential marker of adverse childhood environments, and Ménière's may suggest that early-life environmental exposures that influence skeletal growth may also influence the risk of developing Ménière's in later life.</p>
4 Authors
- Jessica S. Tyrrell
- Mark S. Taylor
- David Whinney
- Nicholas J. Osborne
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