| Title: | Periodontitis and outer retinal thickness: A cross-sectional analysis of the UK Biobank cohort |
| Journal: | Ophthalmology Science |
| Published: | 1 Jan 2024 |
| DOI: | https://doi.org/10.1016/j.xops.2024.100472 |
| URL: | http://www.ophthalmologyscience.org/article/S2666914524000083/pdf |
Publication 9033
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Purpose Periodontitis, a ubiquitous severe gum disease affecting the teeth and surrounding alveolar bone can heighten systemic inflammation. We investigated the association between very severe periodontitis and early biomarkers of age-related macular degeneration, in individuals with no eye disease. Design Cross-sectional analysis of the prospective community-based cohort United Kingdom (UK) Biobank. Participants Sixty-seven thousand three hundred eleven UK residents aged 40-70 years recruited between 2006-2010 underwent retinal imaging. Methods Macular-centered optical coherence tomography images acquired at the baseline visit were segmented for retinal sublayer thicknesses. Very severe periodontitis was ascertained through a touchscreen questionnaire. Linear mixed effects regression modeled the association between very severe periodontitis and retinal sublayer thicknesses adjusting for age, sex, ethnicity, socioeconomic status, alcohol consumption, smoking status, diabetes mellitus, hypertension, refractive error, and previous cataract surgery. Main Outcome Measures Photoreceptor layer (PRL) and retinal pigment epithelium-Bruch's membrane (RPE-BM) thicknesses. Results Among 36,897 participants included in the analysis, 1,571 (4.3%) reported very severe periodontitis. Affected individuals were older, lived in areas of greater socioeconomic deprivation and were more likely to be hypertensive, diabetic and current smokers (all p<0.001). On average, those with very severe periodontitis were myopic (-0.29 ± 2.40 diopters) while those unaffected were hyperopic (0.05 ± 2.27 diopters, p<0.001). Following adjusted analysis, very severe periodontitis was associated with thinner PRL (-0.55 μm, 95% CI: -0.97, -0.12, p=0.022) but there was no difference in RPE-BM thickness (0.00 μm, 95% CI: -0.12, 0.13, p=0.97). The association between PRL thickness and very severe periodontitis was modified by age (p<0.001). Stratifying individuals by age, thinner PRL was seen among those aged 60-69 years with disease (-1.19 μm, 95% CI: -1.85, -0.53, p<0.001) but not among those under 60 years. Conclusions Among those with no known eye disease, very severe periodontitis is statistically associated with a thinner PRL, consistent with incipient age-related macular degeneration. Optimizing oral hygiene may hold additional relevance for people at risk of degenerative retinal disease.</p>
97 Authors
- Siegfried K. Wagner
- Praveen J. Patel
- Josef Huemer
- Hagar Khalid
- Kelsey V. Stuart
- Colin J. Chu
- Dominic J. Williamson
- Robbert R. Struyven
- David Romero-Bascones
- Paul J. Foster
- Anthony P. Khawaja
- Axel Petzold
- Konstantinos Balaskas
- Mario Cortina-Borja
- Iain Chapple
- Thomas Dietrich
- Jugnoo S. Rahi
- Alastair K. Denniston
- Pearse A. Keane
- Biobank Eye Vision Consortium
- Naomi Allen
- Tariq Aslam
- Denize Atan
- Konsantinos Balaskas
- Sarah A. Barman
- Jenny H. Barrett
- Paul Bishop
- Graeme Black
- Tasanee Braithwaite
- Roxana O. Carare
- Usha Chakravarthy
- Michelle Chan
- Sharon Y.L. Chua
- Alexander Day
- Parul Desai
- Bal Dhillon
- Andrew D. Dick
- Alexander Doney
- Cathy Egan
- Sarah Ennis
- Paul Foster
- Marcus Fruttiger
- John E.J. Gallacher
- David F. Garway-Heath
- Jane Gibson
- Jeremy A. Guggenheim
- Chris J. Hammond
- Alison Hardcastle
- Simon P. Harding
- Ruth E. Hogg
- Pirro Hysi
- Pearse A. Keane
- Peng T. Khaw
- Anthony P. Khawaja
- Gerassimos Lascaratos
- Thoams Littlejohns
- Andrew J. Lotery
- Robert Luben
- Phil Luthert
- Tom Macgillivray
- Sarah Mackie
- Bernadette McGuinness
- Gareth J. McKay
- Martin McKibbin
- Tony Moore
- James E. Morgan
- Eoin O'Sullivan
- Richard Oram
- Chris G. Owen
- Praveen Patel
- Euan Paterson
- Tunde Peto
- Axel Petzold
- Jugnoo S. Rahi
- Alicja R. Rudnikca
- Naveed Sattar
- Jay Self
- Panagiotis Sergouniotis
- Sobha Sivaprasad
- David Steel
- Irene Stratton
- Nicholas Strouthidis
- Cathie Sudlow
- Zihan Sun
- Robyn Tapp
- Dhanes Thomas
- Emanuele Trucco
- Adnan Tufail
- Veronique Vitart
- Ananth C. Viswanathan
- Mike Weedon
- Cathy Williams
- Katie Williams
- Jayne V. Woodside
- MaxM. Yates
- Jennifer Yip
- Yalin Zheng
1 Application
| Application ID | Title |
|---|---|
| 2112 | Automated macular thickness measurements and association with potential risk factors and systemic disease |
Enabling scientific discoveries that improve human health