| Title: | Association of cholecystectomy with osteoporosis risk: a prospective study using data from the UK Biobank |
| Journal: | Frontiers in Endocrinology |
| Published: | 20 Oct 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37929032/ |
| DOI: | https://doi.org/10.3389/fendo.2023.1259475 |
| URL: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1259475/pdf?isPublishedV2=False |
Publication 9349
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Abstract
Objective: To investigate whether prior cholecystectomy is associated with incident osteoporosis.</p>
Background: Cholecystectomy may have consequences involving abnormal metabolism. Studies investigating the association between prior cholecystectomy and osteoporosis have yielded inconsistent results.</p>
Methods: In total, 17,603 UK Biobank participants underwent cholecystectomy, and 35,206 matched controls were included in this study. They were followed up for incident osteoporosis, which was determined using ICD-10 codes (M80-82). The association between cholecystectomy and osteoporosis was assessed using Cox proportional regression modeling. The association between osteoporosis risk and cholecystectomy was further analyzed across age, sex, serum vitamin D level, and body mass index (BMI) categories.</p>
Results: Within a median follow-up period of 13.56 years, 3,217 participants were diagnosed with osteoporosis. After adjustment for relevant confounders, prior cholecystectomy was associated with a 1.21 times higher risk of osteoporosis in women (hazard ratio (HR): 1.21 [95% CI, 1.12-1.31], p < 0.001) and a 1.45 times higher risk in men (HR: 1.45 [95% CI, 1.10-1.90], p = 0.007). In women, the association was stronger for patients who were aged 40-55 years, with BMI < 18.5 kg/m2, and vitamin D between 30 and 50 nmol/ml. No significant interactions between cholecystectomy and income level, education level, presence of hypertension, or diabetes were identified in either sex.</p>
Conclusions: Our findings indicated that people who underwent cholecystectomy had a higher risk of developing osteoporosis after adjustment for potential confounders. Our findings suggest that awareness of the risk of osteoporosis in patients with a history of cholecystectomy is merited.</p>
6 Authors
- Qin Yang
- Ming Wang
- Tongtong Zhang
- Jun Wen
- Lu Long
- Congying Xia
1 Application
| Application ID | Title |
|---|---|
| 93810 | Identification of genetic variants and lifestyle factors involved in obesity. |
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