| Title: | A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization |
| Journal: | Nature Communications |
| Published: | 11 Jan 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33431812/ |
| DOI: | https://doi.org/10.1038/s41467-020-20368-w |
| URL: | https://www.nature.com/articles/s41467-020-20368-w.pdf |
| Citations: | 45 (24 in last 2 years) as of 8 Aug 2024 |
Publication 9534
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship between 25(OH)D and ten cancers. Our findings are broadly consistent with previous MR studies indicating no relationship, apart from ovarian cancers (OR 0.89; 95% C.I: 0.82 to 0.96 per 1 SD change in 25(OH)D concentration) and basal cell carcinoma (OR 1.16; 95% C.I.: 1.04 to 1.28). However, after adjustment for pigmentation related variables in a multivariable MR framework, the BCC findings were attenuated. Here we report that lower 25(OH)D is unlikely to be a causal risk factor for most cancers, with our study providing more precise confidence intervals than previously possible.</p>
24 Authors
- Jue-Sheng Ong
- Suzanne C. Dixon-Suen
- Xikun Han
- Jiyuan An
- Upekha Liyanage
- Jean-Cluade Dusingize
- Johannes Schumacher
- Ines Gockel
- Anne Böhmer
- Janusz Jankowski
- Claire Palles
- Tracy O'Mara
- Amanda Spurdle
- Matthew H. Law
- Mark M. Iles
- Paul Pharoah
- Andrew Berchuck
- Wei Zheng
- Aaron P. Thrift
- Catherine Olsen
- Rachel E. Neale
- Puya Gharahkhani
- Penelope M. Webb
- Stuart MacGregor
1 Application
| Application ID | Title |
|---|---|
| 25331 | Gene mapping and genetic correlation across complex traits |
Enabling scientific discoveries that improve human health