UKB WES Protocol (September 2021)

The UKB WES protocol describes the single- and aggregate-sample processing, including read alignment, variant calling, joint genotyping and post aggregation reformatting, employed by the Regeneron Genetics Center to generate the UK Biobank WES data set for public release. Following this protocol, researchers can aggregate their own sequencing data with the UK Biobank single sample data, enabling mega-analysis.

This resource can be downloaded or viewed using the link: UKB_WES_Protocol.pdf

If you have wget available (typically on linux systems), then you can also obtain a copy using the command

 wget  -nd  biobank.ctsu.ox.ac.uk/ukb/ukb/docs/UKB_WES_Protocol.pdf