| Title: | Association and Interaction of Genetics and Area-Level Socioeconomic Factors on the Prevalence of Type 2 Diabetes and Obesity. |
| Journal: | Diabetes Care |
| Published: | 14 Feb 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36787958/ |
| DOI: | https://doi.org/10.2337/dc22-1954 |
| URL: | https://doi.org/10.2337/figshare.21754235 |
Publication 7943
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Abstract
OBJECTIVE: Quantify the impact of genetic and socioeconomic factors on risk of type 2 diabetes (T2D) and obesity. RESEARCH DESIGN AND METHODS: Among participants in the Mass General Brigham Biobank (MGBB) and UK Biobank (UKB), we used logistic regression models to calculate cross-sectional odds of T2D and obesity using 1) polygenic risk scores for T2D and BMI and 2) area-level socioeconomic risk (educational attainment) measures. The primary analysis included 26,737 participants of European genetic ancestry in MGBB with replication in UKB (N = 223,843), as well as in participants of non-European ancestry (MGBB N = 3,468; UKB N = 7,459). RESULTS: The area-level socioeconomic measure most strongly associated with both T2D and obesity was percent without a college degree, and associations with disease prevalence were independent of genetic risk (P < 0.001 for each). Moving from lowest to highest quintiles of combined genetic and socioeconomic burden more than tripled T2D (3.1% to 22.2%) and obesity (20.9% to 69.0%) prevalence. Favorable socioeconomic risk was associated with lower disease prevalence, even in those with highest genetic risk (T2D 13.0% vs. 22.2%, obesity 53.6% vs. 69.0% in lowest vs. highest socioeconomic risk quintiles). Additive effects of genetic and socioeconomic factors accounted for 13.2% and 16.7% of T2D and obesity prevalence, respectively, explained by these models. Findings were replicated in independent European and non-European ancestral populations. CONCLUSIONS: Genetic and socioeconomic factors significantly interact to increase risk of T2D and obesity. Favorable area-level socioeconomic status was associated with an almost 50% lower T2D prevalence in those with high genetic risk.12 Authors
- Sara J Cromer
- Chirag M Lakhani
- Josep M Mercader
- Timothy D Majarian
- Philip Schroeder
- Joanne B Cole
- Jose C Florez
- Chirag J Patel
- Alisa K Manning
- Sherri-Ann M Burnett-Bowie
- Jordi Merino
- Miriam S Udler
1 Application
| Application ID | Title |
|---|---|
| 27892 | Genetic studies of type 2 diabetes, related metabolic traits, and their complications |
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