| Title: | Lifestyle risk factors in association with dementia risk |
| Lead Institution: | University of Oxford |
| Principal investigator: | Professor John Gallacher |
Application 15697
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About
The MRC Dementias Platform UK (DPUK) is a multi-cohort collaboration. This proposal is to use UKB data alongside that of other cohorts to investigate the determinants of dementia. To do this we will need to compare cognitive and lifestyle data in those with and without dementia. We will need to take account of co-morbidities, family history, genetics imaging and biomarkers. Dementia is a major public health problem and one of the chronic diseases that UKB was established to investigate We will compare risk factors for dementia prevalence and incidence within cohorts and between cohorts. This is a statistical analysis of existing data. UKB will be used to generate hypotheses which will be tested in confirmatory analyses using other DPUK cohorts. full cohort5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 8273 | A psychometric evaluation of the 16-item PHQ-ADS concomitant anxiety and depression scale in the UK biobank using item response theory | Chris Patrick Pflanz (+2) | 2023 | Journal of Affective Disorders |
| 9815 | Cumulative life course adversity, mental health, and cognition in the UK biobank | M. Künzi (+5) | 2022 | Scientific Reports |
| 9955 | Distress and neuroticism as mediators of the effect of childhood and adulthood adversity on cognitive performance in the UK Biobank study | Chris Patrick Pflanz (+3) | 2024 | Scientific Reports |
| 9456 | Education is power: preserving cognition in the UK biobank | Benjamin Tari (+4) | 2023 | Frontiers in Public Health |
| 7998 | Research-ready data: the C-Surv data model | Sarah Bauermeister (+10) | 2023 | European Journal of Epidemiology |
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