| Title: | Investigating the genetics, behavior, environmental and clinical determinants and their interaction of nervous system diseases and other non-communicated diseases |
| Lead Institution: | First Affiliated Hospital of Zhengzhou University |
| Principal investigator: |
Application 186039
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About
Nervous system diseases, such as cerebrovascular disease, and neurodegenerative diseases have become the main challenges to global public health. Without a cure or prevention, nervous system diseases will quickly become an overwhelming economic and social burden. However, our current understanding of nervous system diseases remains limited. In addition, the association between different nervous system diseases and the relationship between nervous system diseases and other diseases is still not fully explored. Therefore, this study aims to investigate the risk factors, predictors, natural trajectory, and prognosis of neurological and non-communicable diseases. Based on the unique UK Biobank resource, we aim to identify the shared risk factors, such as lifestyle, environmental exposures, physical, nutritional, biochemical, and genetic factors, including dietary habits, exercise behavior, smoking, alcohol consumption, nutrient intake, beverage intake and sleep of nervous system diseases and other non-communicated diseases. We also explore the intrinsic connection between different neurological diseases and those with other non-communicable diseases. At last, we will identify pathological mechanisms for nervous system diseases and other common non-communicable diseases, and provide effective prediction models for the incidence and progression of nervous system outcomes. We plan to apply for the whole cohort, and the proposed duration is 3 years.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 14693 | Association between migraine and cerebral white matter hyperintensities in middle-aged and older individuals: A cross-sectional study using the UK Biobank cohort | Peng-Peng Niu (+4) | 2025 | Headache The Journal of Head and Face Pain |
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