| Title: | The effect of genetic variants on pregnancy complications and its long term health outcomes |
| Lead Institution: | Seoul National University |
| Principal investigator: | Professor Seung Mi Lee |
Application 68416
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About
Summary: Pregnancy complications can result in long term complications. The identification who are likely to develop these risks will help clinicians and patients to develop preventable strategies. For this purpose, we would like to find genetic causes which can result in the pregnancy complications and their long term complications later in life. Aims: Our purpose is to evaluate of the effect of genetic factors on pregnancy complications and its long term health outcomes. For this purpose, 1) We will first analyze genetic causes which can be associated with pregnancy outcomes, and 2) We will analyze these long term outcomes after pregnancy complications, and 3) We will evaluate which genetic factors can role as the bridges between pregnancy complications and long term complications. Scientific rationale: Pregnancy complications such as preeclampsia, gestational diabetes, spontaneous abortion or preterm birth can result in long term complications, including cardiovascular disease and neurocognitive impairment. We would like to find genetic causes which can result in the pregnancy complications and their long term complications later in life. Project duration: This project will require several years, at least 3 years. Public health impact: This study will help clinicians and patients to develop preventable strategies. Researchers will get more information for the development of new interventions and therapeutic targets. Better identification of high risk group will be also be used for policies and should allow a reduction of complication rates and associated healthcare costs.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7229 | A Network-Based Analysis of Disease Complication Associations for Obstetric Disorders in the UK Biobank | Vivek Sriram (+6) | 2021 | Journal of Personalized Medicine |
| 8222 | Future risk of metabolic syndrome after recurrent pregnancy loss: a cohort study using UK Biobank | Ji Hye Bae (+9) | 2023 | Fertility and Sterility |
| 11209 | Genome-wide polygenic risk scores for hypertensive disease during pregnancy can also predict the risk for long-term cardiovascular disease | Seung Mi Lee (+11) | 2023 | American Journal of Obstetrics and Gynecology |
| 10630 | Long-term cardiovascular outcomes of gestational diabetes mellitus: a prospective UK Biobank study | Seung Mi Lee (+10) | 2022 | Cardiovascular Diabetology |
| 7219 | Long-term cardiovascular outcomes of gestational diabetes mellitus: a prospective population-based UK Biobank study | Seung Mi Lee (+10) | 2022 | American Journal of Obstetrics and Gynecology |
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