| Title: | The relationship and genetic association of high resting heart rate and myocardial remodeling |
| Lead Institution: | Xi'an Jiaotong University |
| Principal investigator: | Miss Mengyao Qi |
Application 68722
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
Heart failure is a major cause of morbidity and mortality worldwide, with a prevalence rate of more than 10% in people over 70 years of age, a four-year mortality rate of 50% in patients with heart failure, and a one-year mortality rate of 50% in patients with severe heart failure. Age-adjusted mortality of heart failure is also on the rise. Despite advances in the treatment of heart failure, the death rate continues to increase.High resting heart rate is a risk factor and an important prognostic indicator for patients with heart failure, and myocardial remodeling runs through the whole process of heart failure development, suggesting that high resting heart rate may be related to myocardial remodeling.However, the relationship and genetic association between them is unclear, and no research has been conducted to investigate their shared genetic mechanisms and causal relationships.This study aims to identify the susceptibility genes shared between high resting heart rate and cardiac remodeling, providing new prevention and treatment strategies for heart failure caused by this condition.We will use the extensive population data from UKBiobank to analyse the complex causes and interactions between them and discover the basis for genetic risk. We will combine this information with data from other heart failure studies and examine whether there are differences in the genetic code associated with different types and populations of heart failure. We will use at least 6 months to analysis data and write paper. The project has the potential to provide new information about genetic factors associated with heart failure that could help prevent, diagnose and treat it.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7900 | Conventional and genetic associations between resting heart rate, cardiac morphology and function as assessed by magnetic resonance imaging: Insights from the UK biobank population study | Yao Ma (+5) | 2023 | Frontiers in Cardiovascular Medicine |
| 8785 | The role of cardiac remodeling associated with renal function in mediating cardiovascular event outcomes | Zhi Lv (+6) | 2024 | iScience |
Enabling scientific discoveries that improve human health