| Title: | Pathogens and age-related chronic diseases |
| Lead Institution: | Xi'an Jiaotong University |
| Principal investigator: | Dr Lei Zhang |
Application 79244
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About
The public health burden of age-related chronic diseases, including cardiovascular diseases and cognitive impairment, increases rapidly with an aging population. Previous studies have reported that pathogens (e.g. COVID-19) could cause the onset and progression of chronic diseases, especially in the elderly population. However, these studies failed to quantify these associations sufficiently due to their small sample sizes and unrelated factors (e.g. gender). UK biobank consists of a large population sample of 500,000 individuals and provides high-quality information on the disease effects of pathogens. We aim to explore the associations between pathogens and age-related chronic diseases and establish risk prediction models for age-related chronic diseases on an individual level. The tentative duration of the project is 36 months. We anticipate that the study findings would provide evidence supports for reducing the onset and deaths due to age-related chronic diseases in the UK and other global settings.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9785 | Adiposity indicators exhibit depot- and sex-specific associations with multimorbidity onset: A cohort study of the UK Biobank | Lu Ma (+10) | 2024 | Diabetes Obesity and Metabolism |
| 9176 | Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom | Yining Bao (+17) | 2023 | BMC Medicine |
Enabling scientific discoveries that improve human health