| Title: | Association between night shift work and NAFLD |
| Lead Institution: | Zhejiang University |
| Principal investigator: | Dr Hangkai Huang |
Application 79302
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About
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease, affecting nearly one third of adults worldwide. The climbing prevalence of NAFLD was fueled by the rapid rise in obesity, type 2 diabetes, cardiovascular disease and other cardiometabolic diseases. NAFLD patients are associated with increased risks of hepatocellular carcinoma as well as extra-hepatic cancers. The burden of NAFLD prevalence has posed a big challenge to global health resources. It is urgent to explore the way of timely prevention and intervention of NAFLD. Mounting evidence has confirmed that shift work posed negative impact on individual health. In particular, long-term night shift work was associated with the increased risks of diabetes, atrial fibrillation, ischemic stroke and other cardiometabolic diseases. However, the association between night shift work and NAFLD was unclear. This proposed study aims to explore whether individuals with night shift work carry higher risks of developing NAFLD. This study will potentially provide evidence of the adverse impact of night shift work on NAFLD and reveal new approaches to prevent the development and progression of NAFLD.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 10314 | Association between night shift work and NAFLD: a prospective analysis of 281,280 UK Biobank participants | Hangkai Huang (+3) | 2023 | BMC Public Health |
| 10932 | Dietary Patterns and Long-Term Outcomes in Patients with NAFLD: A Prospective Analysis of 128,695 UK Biobank Participants | Zhening Liu (+3) | 2023 | Nutrients |
| 9202 | Different dietary carbohydrate component intakes and long-term outcomes in patients with NAFLD: results of longitudinal analysis from the UK Biobank | Zhening Liu (+4) | 2023 | Nutrition Journal |
| 10246 | Modifiable lifestyle factors, genetic and acquired risk, and the risk of severe liver disease in the UK Biobank cohort (Lifestyle factors and SLD) | Zhening Liu (+4) | 2023 | Digestive and Liver Disease |
| 8275 | The sulfur microbial diet and risk of nonalcoholic fatty liver disease: a prospective gene-diet study from the UK Biobank | Zhening Liu (+4) | 2023 | American Journal of Clinical Nutrition |
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