| Title: | Sex and Gender Differences in Patients with Heart Failure |
| Lead Institution: | University Medical Center Groningen |
| Principal investigator: | Dr Hailun Qin |
Application 80120
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
Rationale: Heart failure is a complex clinical syndrome, with distinct differences between men and women. The most notable sex difference can be observed in the development of heart failure phenotypes, in which men are predisposed to developing heart failure with a reduced ejection fraction (HFrEF), whereas women predominate in heart failure with a preserved ejection fraction (HFpEF). Despite common cardiovascular risk factors in men and women, women are more vulnerable to developing heart failure under the influence of menopausal status, reproductive factors and sex-specific comorbidities such as breast cancer. Gender is a psychosocial construct, and relects social norms, expectations, roles, behaviors, expressions and identities ascribed to women and men, in contrast to biological characteristics that are captured by sex. Unlike sex, gender-related characteristics, such as personality traits and social roles, can be present at different levels in both women and men. In the general population, higher femininity scores were associated with a lower risk of coronary heart disease mortality in men but not in women. Feminine gender was associated with a higher presence of cardiovascular disease risk factors, independently of sex. In addition, feminine gender is a strong predictor of the recurrent acute coronary syndrome, and patients with feminine personality traits have poorer access to care. However, much less is known in gender differences in patients with new-onset heart failure. Aims and Duration: Whether traditional gender roles and gender stereotyping ascribed to women are associated with new-onset HFrEF and HFpEF is unknown. We aimed to determine whether sex and/or gender-related characteristics are associated with new-onset HFrEF, HFmrEF and HFpEF. Also, we will investigate women-specific risk factors for the development of heart failure. This project will take approximately 3 years after get access to the data. Public health impact: A better understanding of the association between sex and gender and the development of heart failure could identify at-risk individuals, may provide opportunities to intervene early in the heart failure process, could ultimately lead to personalized treatment strategies and improve the prognostication in patients with heart failure.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 14481 | Alcohol consumption and incident heart failure in men and women | Hailun Qin (+3) | 2025 | European Journal of Heart Failure |
| 14050 | Clinical and Proteomic Risk Profiles of New-Onset Heart Failure in Men and Women | Hailun Qin (+9) | 2024 | JACC Heart Failure |
Enabling scientific discoveries that improve human health