| Title: | Identify risk factors, clinical subtypes, treatment and prevention of chronic kidney disease |
| Lead Institution: | Tianjin Medical University |
| Principal investigator: |
Application 91377
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About
The aims of the current project are to investigate the association between the following factors, including smoking, alcohol, blood lipids, body composition, diets, inflammatory and other laboratory examinations, history of medicine and disease, ECG data, and data from MRI scans. Chronic kidney disease (CKD) is a progressive disease with high morbidity and mortality. The global burden of CKD is substantial. There were 697.5 million CKD patients worldwide in 2017, resulting in 1.2 million deaths each year. It will become the fifth leading cause of death worldwide by 2040. The early stage of DKD is a controllable and preventable critical stage. Early intervention could help to reverse urinary protein and reduce the occurrence of end-stage renal disease. Once the patient reached the proteinuria stage, even if the application of strict control of blood glucose, blood pressure, and adequate RAS blockers is still unable to completely prevent the progression of DN and the occurrence of end-stage renal disease. In summary, for the prevention and control of CKD, it is crucial to find the real causes of ongoing kidney damage. Furthermore, the identification of different subtypes is more relevant to understand the mechanism and for targeted drug development. The current project will aim to identify novel modifiable risk factors for CKD. For the prevention and control of CKD, it is crucial to find the real causes of ongoing kidney damage. Furthermore, the identification of different subtypes is more relevant to understand the mechanism and for targeted drug development. Given the limited knowledge currently existing with regard to risk factors for CKD, there is a great need for studies on this disease.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9077 | Association between circadian physical activity patterns and cancer incidence through regulation of inflammation: A UK biobank study | Pufei Bai (+9) | 2023 | Preventive Medicine |
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