| Title: | Causal relationships between lifestyle and environment exposures and neurodegenerative and cerebrovascular diseases |
| Lead Institution: | Fujian Medical University |
| Principal investigator: |
Application 94166
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About
Neurodegenerative and cerebrovascular diseases, including Parkinson's, Alzheimer's, amyotrophic lateral sclerosis, frontotemporal dementia, vascular dementia, multiple system atrophy, progressive supranuclear palsy, sleep behavior disorder, secondary Parkinson's disease, cerebral infarction, etc., its economic burden accounts for more than 50% of the world's medical expenditure. Lifestyle and environment exposures, including dietary habits, exercise behavior, smoking, alcohol consumption, nutrient intake, beverage intake, and sleep have been associated with the risk of these diseases. We aim to explore the associations between Lifestyle and environment exposures and neurodegenerative and cerebrovascular diseases in a large population-based cohort study. Our project will provide evidence for developing efficient strategies to reduce morbidity and mortality of neurodegenerative and cerebrovascular diseases. This project is expected to last for 36 months. The findings may deepen the understanding of associations between different exposures and neurodegenerative and cerebrovascular diseases and their related outcomes, and may provide strong evidence for the prevention and therapeutic strategy of neurodegenerative and cerebrovascular diseases, and even make a significant contribution to global public health.3 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 10304 | Association of pro-inflammatory diet with increased risk of all-cause dementia and Alzheimer's dementia: a prospective study of 166,377 UK Biobank participants | Yisen Shi (+7) | 2023 | BMC Medicine |
| 9014 | Association of time spent outdoors with the risk of Parkinson's disease: a prospective cohort study of 329,359 participants | Ling Hu (+6) | 2024 | BMC Neurology |
| 8854 | Fish oil supplementation, physical activity and risk of incident Parkinson's disease: results of longitudinal analysis from the UK Biobank | Fabin Lin (+13) | 2024 | Frontiers in Aging Neuroscience |
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