| Application: | 10279, The relationship of cognitive function and negative emotions with morbidity and mortality: an aetiological investigation |
| Title: | GWAS on family history of Alzheimer's disease |
| Size: | 371961 B |
| Archived: | 3 Nov 2020 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 2772
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Notes
We took advantage of a novel approach to GWAS, whereby we studied parental history of Alzheimer's disease with genetics in the offspring (the UK Biobank participants). We integrated (meta-analysed) these results with the largest GWAS of Alzheimer's to date and identified 3 novel single-variant associations, and multiple novel gene-based associations. Some of these new findings are potential drug targets for other diseases and disorders.The summary statistics from the genetic analysis are available at https://www.ccace.ed.ac.uk/node/335.
Application 10279
The relationship of cognitive function and negative emotions with morbidity and mortality: an aetiological investigation
The proposed research aims to understand why it is that poorer cognitive function and negative emotional factors are typically associated with poorer health and increased mortality. We shall use health outcome data to examine how all-cause mortality and incident cancer and cardiovascular disease (CVD)vary according to prior cognitive function and negative emotions. We shall investigate the extent to which relationships we find between cognition, emotions and these health outcomes are explained or modified by physical, biological, genetic, behavioural, and socio-demographic factors. Genetic analyses will incorporate multivariate genome-wide complex trait analysis and polygenic prediction of these relationships. Poorer cognitive function and negative emotional states and traits have been shown to increase mortality but the reasons for this are unclear. We anticipate that the proposed research will: 1) show us how mortality and morbidity from common health conditions vary according to prior cognitive abilities and emotional factors; 2) reveal potential mechanisms whereby poorer cognition and negative emotion increase risk; and 3) identify whether other characteristics can increase or reduce the risk of ill health in those with poorer cognition and negative emotions. This information could help inform intervention strategies for preventing or treating common health conditions. Using data on cognitive function and negative emotions together with data collected on health outcomes, scientists at the Centre for Cognitive Ageing and Cognitive Epidemiology will examine whether cognitive performance and emotional states predict risk of all-cause mortality and the onset of cancer and CVD. They will investigate whether other characteristics, such as lifestyle, socio-demographic, physical, behavioural or biological factors, help to explain any links between cognitive function and emotions and these health outcomes. They will estimate degree of genetic sharing between: 1) cognitive function/emotions and these characteristics, and 2) cognitive function/emotions and health outcomes. The full cohort
| Lead investigator: | Dr Michelle Luciano |
| Lead institution: | University of Edinburgh |
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| 760 | 10279 | Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112151) | 17 Oct 2017 |
| 762 | 10279 | Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions | 17 Oct 2017 |
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| 3184 | 10279 | The influence of X chromosome variants on trait neuroticism | 9 Mar 2021 |
| 1850 | 10279 | When Is Higher Neuroticism Protective Against Death? Findings From UK Biobank | 6 Dec 2019 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 2773 | GWAS on family history of Alzheimer's disease | Riccardo E. Marioni (+16) | 2018 | Translational Psychiatry |
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