Sex differences general and central obesity
Excess adipose tissue is a major risk factor for myocardial infarction (MI). There are substantial differences in the distribution of adipose tissue between women and men. in this study, we assessed the sex-specific relationships, and their differences, between measures of general and central adiposity and the risk of incident MI. Measures of central adiposity (waist circumference, waist-to-hip ratio, and waist-to-height ratio), but not of general adiposity (body mass index), were more strongly associated with the risk of MI in women than in men. Measures of central adiposity, particularly waist-to-hip ratio, were more strongly associated with the risk of MI than general adiposity, especially among women. Thus, this study suggests that the sex dimorphism in the quantity and distribution of adipose tissue not only results in differences in body shape between women and men, but may also have differential implications for the risk of MI in later life.
Sex differences in the association between major and modifiable risk factors with cardiovascular disease
Most of the burden of cardiovascular diseases (CVD) is explained by a composite of physiological and lifestyle factors - chiefly, elevated blood pressure, obesity, diabetes, cigarette smoking, poor diet, and physical inactivity. There is increasing evidence that some of these risk factors have stronger effects on CVD in women than men. Although preventive strategies aimed at lowering the burden of these risk factors will benefit all, a sound knowledge of whether there are meaningful sex differences in relationships between traditional chronic disease risk factors and disease outcomes should help promote development of effective, sex-specific interventions. Addressing sex differences in relationships between risk factors and CVD risk is of importance from clinical and public health perspectives. Identifying significant sex differences in how risk factors relate to CVD risk should provide an impetus for targeted interventions aimed at reducing the prevalence of disease. Moreover, sex-specific estimates of disease risks associated with modifiable risk factors are essential for accurate estimation of the burden of disease due to these factors. These findings would help to inform the decision making process to maximize the efficacy of the allocation of health care resources, both in the UK and worldwide. Sex-specific estimates for the association between common lifestyle risk factors (elevated blood pressure, obesity, diabetes, cigarette smoking and a poor diet) and the risk of incident CVD will be determined. These sex-specific estimates will be used to evaluate whether or not the risk of stroke and coronary disease associated with these risk factors is similar between women and men. Analyses will be conducted in all individuals, as well as in subgroups defined by age, so as to identify sex-specific changes with ageing (for example, post-menopause), and socioeconomic status, to explore the effects of deprivation. Baseline and follow-up data on the full cohort of women and men in the UK Biobank, except those with pre-existing CVD at baseline, are requested.
|Lead investigator:||Professor Mark Woodward|
|Lead institution:||George Institute for Global Health|
7 related Returns
|Return ID||App ID||Description||Archive Date|
|3433||2495||Diabetes, glycated haemoglobin and the risk of myocardial infarction in women and men: a prospective cohort study of the UK Biobank.||21 May 2021|
|3542||2495||Oestradiol and the risk of myocardial infarction in women: a cohort study of UK Biobank participants||9 Jun 2021|
|1468||2495||Sex differences in body anthropometry and composition in individuals with and without diabetes in UK Biobank||5 Jul 2018|
|2172||2495||Sex differences in macronutrient intake and adherence to dietary recommendations: findings from the UK Biobank||9 Apr 2020|
|2795||2495||Sex differences in risk factors for myocardial infarction: cohort study of UK Biobank participants||4 Nov 2020|
|2787||2495||Women's reproductive factors and incident cardiovascular disease in the UK Biobank.||4 Nov 2020|
|1469||2495||Women's reproductive health factors and body adiposity: findings from the UK Biobank||5 Jul 2018|
|2789||Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank||Peters SAE et al.||2018||J Am Heart Assoc|