Context: UK Biobank is a prospective study of half a million subjects, almost all aged 40 69 years, identified in 22 centres across the UK during 2006 2010.
Objective: A healthy lifestyle has been described as better than any pill, and no side effects . We therefore examined the relationships between healthy behaviours: low alcohol intake, non-smoking, healthy BMI, physical activity and a healthy diet, and the risk of all cancers, colon, breast and prostate cancers in a large dataset.
Method: Data on lifestyle behaviours were provided by 343,150 subjects, and height and weight were measured at recruitment. 14,285 subjects were diagnosed with cancer during a median of 5.1 years of follow-up.
Results: Compared with subjects who followed none or a single healthy behaviour, a healthy lifestyle based on all five behaviours was associated with a reduction of about one-third in incident cancer (hazard ratio [HR] 0.68; 95% confidence intervals [CI] 0.63 0.74). Colorectal cancer was reduced in subjects following the five behaviours by about one-quarter (HR 0.75; 95% CI 0.58 0.97), and breast cancer by about one-third (HR 0.65; 95% CI 0.52 0.83). The association between a healthy lifestyle and prostate cancer suggested a significant increase in risk, but this can be attributed to bias consequent on inequalities in the uptake of the prostate specific antigen screening test.
Conclusions: Taken together with reported reductions in diabetes, vascular disease and dementia, it is clearly important that every effort is taken to promote healthy lifestyles throughout the population, and it is pointed out that cancer and other screening clinics afford teachable moments for the promotion of a healthy lifestyle.
The impact of smoking, alcohol and adiposity on health outcomes in the UK Biobank
The proposal is to investigate the impact of three classic risk factors (smoking, alcohol and adiposity, each of which can affect many different diseases) on a wide range of health outcomes in UK Biobank (UKB). Of particular interest will be vascular outcomes and cancer along with cognitive performance and mood. This study will contribute to a greater understanding of how these classic risk factors combine to affect population health.
The initial focus of this work will be to analyse baseline data comparing risk of major chronic disease according to smoking behaviour, alcohol consumption and adiposity. When re-measurement data become available we will use these to improve the precision of our analyses. When prospective data become available we will extend our analyses to include incidence and mortality. Outcome data of interest will include death, cancer registry data and hospital episode data. When bio-marker data become available we will investigate possible mechanisms underlying the associations of these three risk factors with prevalent and incident outcomes. When genetic data become available we will use these to investigate the interaction between genetic and environmental factors and to further investigate possible mechanisms.
The value of the proposed analyses lies in the statistical power that is available from using the entire UKB cohort. This will enable us to provide the most detailed analyses of these important causes of morbidity and mortality to date
|Lead investigator:||Professor John Gallacher|
|Lead institution:||University of Oxford|
2 related Returns
|Return ID||App ID||Description||Archive Date|
|3273||15008||Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants||1 Apr 2021|
|2852||15008||Reflection on modern methods: calculating a sample size for a repeatability sub-study to correct for measurement error in a single continuous exposure||23 Nov 2020|
|2848||Healthy living and cancer: evidence from UK Biobank||Elwood et al||2018||ecancermedicalscience (2018)|