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In a large population-based study of British adults aged 40 to 69 years, an increased serum level of free testosterone was associated with lower odds of physician-diagnosed asthma and current wheeze both in women and men, and associated with lower odds of at least one asthma hospitalization in women. Higher serum free testosterone levels were also associated with higher lung function in men. The findings from this study suggest that serum-free testosterone is linked to lower risk of asthma in both men and women.
The prediction of asthma status using clinical and genetic variables
Asthma is a common and complex disease with substantial heritability. It has been shown that asthma is associated with clinical variables and genetics, but their association to asthma is still not sufficiently characterized. Currently, there is no gold standard for diagnosis of asthma because of its heterogeneity and complexity. Thus, an accurate asthma prediction model is on demand. With the growth of big data in the biomedical community, researchers are able to use a large sample size and large scale of variables to predict disease status with higher accuracy. Thus, in this study, we propose to use deep learning to train a prediction model for asthma diagnosis by using the UK Biobank samples. Our final prediction model will be freely accessible to the research community. This can help asthma to be diagnosed more accurately. We expect that this study takes around 15 months.