| Application: | 43015, Melatonin, lifestyle, and health: a gene-environmental investigation in the UK Biobank |
| Title: | Increased Risk of Myocardial Infarction Among Patients With Type 2 Diabetes Who Carry the Common rs10830963 Variant in the MTNR1B Gene |
| Size: | 463854 B |
| Archived: | 29 Jul 2021 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 3691
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Notes
The common MTNR1B single nucleotide polymorphism rs10830963 associates with risk of type 2 diabetes mellitus (T2D). Here, we examine the association between this gene variant and the risk of myocardial infarction (MCI) among patients with T2D. MCI is a main cause of death and disability among such individuals.Application 43015
Melatonin, lifestyle, and health: a gene-environmental investigation in the UK Biobank
The hormone melatonin produced by the pineal gland during darkness is well-known for its pleiotropic functions in the human body. Experimental research has demonstrated that melatonin is a strong antioxidant, possesses anti-cancerogenic properties, and reduces the activity of peripheral glands, including the pancreatic islets. Various lifestyle factors are known to alter melatonin production, including daytime light exposure, evening artificial light, caffeine, and physical activity. In addition to these lifestyle factors, it has been shown that a common polymorphism in the melatonin receptor 1 B gene (MTNR1B) also alters nocturnal melatonin secretion. Several studies have established a link between this genetic polymorphism and the risk of type 2 diabetes. However, whether lifestyle known to alter melatonin production may moderate associations between common polymorphisms in MTNR1B and risk of type 2 diabetes has not been investigated in large-scale cohorts, such as the UK biobank. Surprisingly, although melatonin possesses cardio-protective and anti-cancerogenic properties, to our best knowledge no study to date has examined whether common polymorphisms in MTNR1B increasing the release of nocturnal melatonin may reduce the disease risk for cardiovascular events (such as myocardial infarcts) and cancers (such as prostate cancer, breast cancer, and colocorectal cancer) frequently found in the general population. With all these gaps in mind, our project has three specific aims: 1. To verify whether subjective parameters of sleep, including sleep duration, chronotype, and sleep disturbances moderate associations between common polymorphisms in the melatonin receptor 1 B gene (MTNR1B) and risk of type 2 diabetes in a large population. 2. To investigate whether diet (e.g. caffeine consumption), light exposure (e.g. time of outdoor activities), and other lifestyle factors moderate associations between common polymorphisms in MTNR1B and risk of type 2 diabetes. 3. To investigate whether common polymorphisms in MTNR1B modify the disease risk for cardiovascular events (such as myocardial infarcts) and highly prevalent cancers (such as prostate cancer, breast cancer, and colocorectal cancer). Findings of this project are likely to provide valuable insight into possible gene-environmental interactions in the pathogenesis of type-2 diabetes, cardiovascular diseases, and cancer.
| Lead investigator: | Dr Xiao Tan |
| Lead institution: | Uppsala University |
1 related Return
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3690 | 43015 | Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank | 29 Jul 2021 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 3692 | Increased Risk of Myocardial Infarction Among Patients With Type 2 Diabetes Who Carry the Common rs10830963 Variant in the MTNR1B Gene | Tan X et al. | 2020 | Diabetes Care |
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