| Application: | 29717, Advancing knowledge on physical activity and health through investigating interrelationships with lifestyle behaviours, fitness, and subclinical outcomes |
| Title: | Stair climbing and mortality: a prospective cohort study from the UK Biobank |
| Size: | 588339 B |
| Archived: | 15 Sep 2021 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 3826
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Notes
BackgroundRegular stair climbing has the potential to lower the risk of premature death, but current evidence is scarce. We aimed to examine whether daily stair climbing is associated with lower risk of all-cause, cancer, and cardiovascular disease (CVD) mortality.
Methods
Using the UK Biobank cohort, we extracted information of self-reported daily flights of stairs climbed at home, categorized as none, 1 to 5, 6 to 10, 11 to 15, and ≥16 flights per day. Associations between flights of stair climbed per day and mortality were examined as hazard ratios (HRs) from Cox proportional hazards models adjusted for demographic, clinical, and behavioural covariates including time spent in other physical activities. We calculated the restricted mean survival time as an absolute measure of association. The risk of residual confounding was examined using propensity score matching and by using lung cancer as negative control outcome. Participants were followed from baseline (2006-2010) through 31 March 2020.
Results
A total of 280 423 participants (median follow-up 11.1 years, during which 9445 deaths occurred) were included. Compared with not climbing any stairs, climbing more than five flights of stairs at home per day was associated with lower risk of premature mortality. The lowest risk was found for those climbing 6-10 flights per day: 0.91; 95% confidence interval (CI): 0.85, 0.98, translated to approximately 44 to 55 days of additional survival. A similar pattern was found after applying propensity score matching and for cancer mortality (6-10 flights per day HR: 0.88; 95% CI: 0.80, 0.97), but not for CVD mortality (6-10 flights per day HR: 1.08; 95% CI: 0.91, 1.29). The association between stair climbing and lung cancer was similar to that of all-cause mortality.
Conclusions
Climbing more than five flights of stairs at home per day was associated with a lower risk of all-cause and cancer mortality, but not CVD mortality, compared with those who did not take the stairs. The magnitude of the association was small and appeared susceptible to residual confounding. It is unlikely that at-home stair climbing is sufficient physical activity stimuli to lower the risk of premature mortality.
Application 29717
Advancing knowledge on physical activity and health through investigating interrelationships with lifestyle behaviours, fitness, and subclinical outcomes
The overall aim is to examine the independent and combined associations between obesity, MVPA, sedentary time and CRF with all-cause, cardio-vascular and cancer mortality. 1. To examine the independent and combined associations of MVPA, obesity, sedentary time and CRF associated with mortality? 2. To examine whether physical activity modify the association between obesity (adiposity) and mortality? 3. To examine whether sedentary time mediate the association between obesity and mortality? Obesity, moderate and vigorous intensity physical activity (MVPA), sedentary time and cardio-respiratory fitness (CRF) are all associated with a number of various health outcomes and mortality. However, the combined associations between these lifestyle variables and mortality is unknown. Further, it is unknown whether objectively measured PA may modify the association between adiposity (BMI and waist circumference) on mortality and whether objectively measured sedentary time may mediate this association. We will quantify how obesity, physical activity sedentary time and fitness are associated with mortality and the relative importance of physical inactivity, obesity, high sedentary time and low fitness on mortality. This will enable important information for intervention strategies and policy makers. Full cohort n=500,000 for most research questions, n~100,000 for the analyses involving cardio-respiratory fitness and objectively measured physical activity.
| Lead investigator: | Dr Ulf Ekelund |
| Lead institution: | Norwegian School of Sport Sciences |
1 related Return
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3825 | 29717 | Physical Activity and Mortality Across Levels of Adiposity: A Prospective Cohort Study From the UK Biobank | 15 Sep 2021 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 3827 | Stair climbing and mortality: a prospective cohort study from the UK Biobank | Miguel A. Sanchez-Lastra (+5) | 2021 | Journal of Cachexia Sarcopenia and Muscle |
Enabling scientific discoveries that improve human health