: Return 3884

Notes

Using genetic data implicated in cardiometabolic and psychiatric illness identified 3 groups of individuals with different cardiometbaolic profiles. Briefly, genetic variants implicated in schizophrenia were identified (loci in the list provided). Those also implicated in cardiometabolic were selected (those on the cardiometabolic chip, list provided). The set of genetic variants was filtered (details in log files) to leave a set of independent variants with complete genotyping. Plink was used with multi-dimensional scaling, to cluster individuals. Visual inspection was used to define the 3 clusters. Standard statistical analyses were used to assess between-cluster differences.

Application 6553

Genome-wide association studies of mental health.

The primary aim of this research is to identify genetic associations with a) major depression plus mania/bipolar disorder, and b) vulnerability to depression and other negative mood states (as measured by neuroticism score). These aims will be achieved by conducting genome-wide association studies (GWAS), making use of data from the UK Biobank genotyping project. This project is linked to previous analyses our team have undertaken on Biobank data in the areas of mood disorder, cognitive function, cardiometabolic disease and ethnicity and meets Biobank?s stated purpose of improving the prevention, diagnosis and treatment of illnesses by identifying genetic risk factors for common mental disorders, as well as genetic risk factors for trait-like vulnerability to these disorders (neuroticism). Insights from this work will lead to a better understanding of disease processes in depression, better approaches to diagnosis and ultimately the development of new treatments. This work will consist of genome-wide association studies (GWAS), making use of data from the UK Biobank genotyping project. These GWAS studies on depression and neuroticism will make use of phenotypic and genetic data on all Biobank participants (full cohort).

Lead investigator:	Dr Rona Strawbridge
Lead institution:	University of Glasgow

9 related Returns

Return ID	App ID	Description	Archive Date
3883	6553	Carotid Intima-Media: Thickness Novel Loci, Sex-Specific Effects, and Genetic Correlations With Obesity and Glucometabolic Traits in UK Biobank	29 Sep 2021
3885	6553	Exploring the Role of Contactins across Psychological, Psychiatric and Cardiometabolic Traits within UK Biobank	29 Sep 2021
3886	6553	Genetic variation in CADM2 as a link between psychological traits and obesity	29 Sep 2021
1963	6553	Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia	4 Feb 2020
1981	6553	Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort	10 Feb 2020
2524	6553	Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide	23 Oct 2020
3378	6553	Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure	26 Apr 2021
2121	6553	Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort	10 Mar 2020
3888	6553	The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function	29 Sep 2021

Application:	6553, Genome-wide association studies of mental health.
Title:	The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically diferent groups of individuals
Size:	4.6 MB
Archived:	29 Sep 2021
Stability:	Complete
Personal:	No individual-level data