| Application: | 3282, Prostate Cancer Epidemiology Consortium: Risk factors for prostate cancer |
| Title: | Lifestyle factors and prostate-specific antigen (PSA) testing in UK Biobank: Implications for epidemiological research |
| Size: | 214681 B |
| Archived: | 5 Jun 2017 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 529
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Notes
Background: The central role of prostate-specific antigen (PSA) testing in the diagnosis of prostate cancer leads to the possibility that observational studies that report associations between risk factors and prostate cancer could be affected by detection bias. This study aims to investigate whether reported risk factors for prostate cancer are associated with PSA testing in a large middle-aged population-based cohort in the UK.Methods: The cross-sectional association between a wide range of sociodemographic, lifestyle, dietary and health characteristics with PSA testing was examined in 212,039 men aged 40 69 years in UK Biobank.
Results: A total of 62,022 (29%) men reported they had ever had a PSA test. A wide range of factors was associated with a higher likelihood of PSA testing including age, height, education level, family history of prostate cancer, black ethnic origin, not being in paid/self-employment, living with a wife or partner, having had a vasectomy, being diagnosed with cancer or hypertension and having a high dietary intake of cereal, cooked and salad/raw vegetables, fresh fruit and tea. Conversely, socioeconomic deprivation, Asian ethnic origin, current smoking, low alcohol intake, high body-mass index, high coffee consumption and being diagnosed with diabetes, heart disease or stroke were associated with a lower likelihood of PSA testing.
Conclusions: A variety of sociodemographic, lifestyle and health-related characteristics are associated with PSA testing, suggesting that observed associations of some of these traits with risk for prostate cancer in epidemiological studies may be, at least partially, due to detection bias.
Littlejohns TJ, Travis RC, Key TJ, Allen NE (2016) Lifestyle factors and prostate-specific antigen (PSA) testing in UK Biobank: Implications for epidemiological research, Cancer Epidemiology, Volume 45, December 2016, Pages 40-46, ISSN 1877-7821, https://doi.org/10.1016/j.canep.2016.09.010
Application 3282
Prostate Cancer Epidemiology Consortium: Risk factors for prostate cancer
Prostate Cancer Epidemiology Consortium We propose a research programme on hormonal, anthropometric, dietary and lifestyle factors and prostate cancer risk; this will extend the work of an existing consortium co-ordinated in the Cancer Epidemiology Unit Oxford, the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. Initially we will describe the distributions of potential prostate cancer risk factors for men in UK Biobank (including personal characteristics, anthropometry, diet, alcohol intake, physical activity and history of use of the prostate-specific antigen (PSA) blood test). This will provide information that will help in the planning of further analyses of prostate cancer by users of Biobank. When at least 2000 cases of prostate cancer have accrued we will begin the main phase of the project, which is to examine the associations between prostate cancer risk and levels of blood biomarkers (including sex hormones, growth factors and nutritional biomarkers such as vitamin D) as well as personal characteristics and lifestyle factors, using a case-cohort design. This project will help us to understand what lifestyle factors are associated with risk and the mechanisms through which they may exert an effect.
| Lead investigator: | Dr Ruth Travis |
| Lead institution: | University of Oxford |
1 related Return
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 2168 | 3282 | Prospective investigation of risk factors for prostate cancer in the UK Biobank cohort study | 9 Apr 2020 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 530 | Lifestyle factors and prostate-specific antigen (PSA) testing in UK Biobank: Implications for epidemiological research | Thomas J. Littlejohns (+3) | 2016 | Cancer Epidemiology |
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